99mTc-labeled monosaccharide kits: development methods and quality control

99mTc-labeled monosaccharide kits: development methods and quality control

Bibliographic Details
Parent link:Scientific Reports
Vol. 10.— 2020.— [5121, 9 p.]
Corporate Author: Национальный исследовательский Томский политехнический университет Физико-технический институт Лаборатория № 31 ядерного реактора
Other Authors: Stasyuk (Stasiuk) E. S. Elena Sergeyevna, Skuridin V. S. Viktor Sergeyevich, Rogov A. S. Alexander Sergeyevich, Zelchan R. V. Roman Vladimirovich, Sadkin V. L. Vladimir Leonidovich, Varlamova N. V. Natalya Valeryevna, Nesterov E. A. Evgeny Alexandrovich
Summary:Title screen
The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma.
Published: 2020
Subjects:
электронный ресурс
труды учёных ТПУ
cancer imaging
drug development
визуализация
рак
разработка
лекарства
Online Access:http://earchive.tpu.ru/handle/11683/65323
https://doi.org/10.1038/s41598-020-61707-7
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662005

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