99mTc-labeled monosaccharide kits: development methods and quality control

99mTc-labeled monosaccharide kits: development methods and quality control

التفاصيل البيبلوغرافية
Parent link:	Scientific Reports Vol. 10.— 2020.— [5121, 9 p.]
مؤلف مشترك:	Национальный исследовательский Томский политехнический университет Физико-технический институт Лаборатория № 31 ядерного реактора
مؤلفون آخرون:	Stasyuk (Stasiuk) E. S. Elena Sergeyevna, Skuridin V. S. Viktor Sergeyevich, Rogov A. S. Alexander Sergeyevich, Zelchan R. V. Roman Vladimirovich, Sadkin V. L. Vladimir Leonidovich, Varlamova N. V. Natalya Valeryevna, Nesterov E. A. Evgeny Alexandrovich
الملخص:	Title screen The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma.
اللغة:	الإنجليزية
منشور في:	2020
الموضوعات:	электронный ресурс труды учёных ТПУ cancer imaging drug development визуализация рак разработка лекарства
الوصول للمادة أونلاين:	http://earchive.tpu.ru/handle/11683/65323 https://doi.org/10.1038/s41598-020-61707-7
التنسيق:	الكتروني فصل الكتاب
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662005

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