99mTc-labeled monosaccharide kits: development methods and quality control
| Parent link: | Scientific Reports Vol. 10.— 2020.— [5121, 9 p.] |
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| Autor corporatiu: | |
| Altres autors: | , , , , , , |
| Sumari: | Title screen The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma. |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | http://earchive.tpu.ru/handle/11683/65323 https://doi.org/10.1038/s41598-020-61707-7 |
| Format: | Electrònic Capítol de llibre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662005 |
| Sumari: | Title screen The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma. |
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| DOI: | 10.1038/s41598-020-61707-7 |