Biomimetic drug delivery platforms based on mesenchymal stem cells impregnated with light-responsive submicron sized carriers; Biomaterials Science; Vol. 8, iss. 4

Biomimetic drug delivery platforms based on mesenchymal stem cells impregnated with light-responsive submicron sized carriers; Biomaterials Science; Vol. 8, iss. 4

書誌詳細
Parent link:Biomaterials Science
Vol. 8, iss. 4.— 2020.— [P. 1137-1147]
団体著者: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
その他の著者: Muslimov A. R. Albert Radikovich, Timin A. S. Aleksandr Sergeevich, Bichaykina V. R. Valeriya, Peltek A. O. Aleksey Olekseevich, Karpov T. E. Timofey Evgenjevich, Dubavik A. Aleksey, Nomine A. Alexandre, Ghanbaja J. Jaafar, Sukhorukov G. B. Gleb Borisovich, Zyuzin M. V. Mikhail
要約:Title screen
Synthetic organic and inorganic carriers often have limitations associated with problematic targeting ability or non-optimized pharmacokinetics, and, therefore, they have restricted therapeutic potential. Natural drug carriers (e.g. mesenchymal stem cells, MSCs) are able to migrate towards the tumor site and penetrate cancerous cells. These biomimetic features make MSCs an attractive delivery platform that allows achieving maximal therapeutic efficiency with minimal toxic side effects. A combination of MSCs exhibiting a homing effect on tumors with stimuli-responsive nanostructured carriers is foreseen to have a huge impact in the field of personalized oncology. Here we develop for the first time a light-sensitive biomimetic delivery platform based on MSCs impregnated with submicron sized composite capsules containing an antitumor drug. This cell-based delivery system triggers the release of the drug upon near-infrared (NIR) laser irradiation due to gold nanorods (Au NRs) incorporated into the capsule wall. The NIR-triggered release of the antitumor drug such as vincristine leads to the effective mortality of tumor spheroids made of primary melanoma cells. Encapsulated vincristine delivered by MSCs into the tumor spheroids and deployed over the whole spheroid upon NIR exposure represents a promising therapy for the improved treatment of malignant neoplasms.
Режим доступа: по договору с организацией-держателем ресурса
言語:英語
出版事項: 2020
主題:
электронный ресурс
труды учёных ТПУ
биомиметические структуры
лекарства
стволовые клетки
светочувствительные системы
субмикронные частицы
オンライン･アクセス:https://doi.org/10.1039/C9BM00926D
フォーマット: 電子媒体 図書の章
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=661957

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