Protective Effects of Pyruvic Acid Salt Against Lithium Toxicity andOxidative Damage in Human Blood Mononuclear Cells; Advanced Pharmaceutical Bulletin (APB); Vol. 9, iss. 2

Protective Effects of Pyruvic Acid Salt Against Lithium Toxicity andOxidative Damage in Human Blood Mononuclear Cells; Advanced Pharmaceutical Bulletin (APB); Vol. 9, iss. 2

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Parent link:Advanced Pharmaceutical Bulletin (APB)
Vol. 9, iss. 2.— 2019.— [P. 302-306]
Korporativní autor: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Další autoři: Plotnikov E. V. Evgeny Vladimirovich, Losenkov I. S. Innokenty Sergeevich, Epimakhova E. V., Bokhan N. A. Nikolay Aleksandrovich
Shrnutí:Title screen
Purpose: Aim of present work was to study cytoprotective properties of lithium pyruvate, as a prospective pharmacological agent. Pyruvate has a lot of potential benefits due to positive influence on cell metabolism. Lithium is “gold-standard” mood-stabilizer. Combination of both may lead advantages. Methods: Lithium pyruvate was tested as cytoprotector on human blood mononuclears under induced oxidative stress. Cells were obtained from healthy donors and patients with alcoholism. The detection of cell viability, apoptosis and determination of oxidative stress level were conducted by flow cytometry. Results: Lithium pyruvate showed excellent cytoprotective properties in normal and oxidation conditions. This effect was independent from cell donor health status. It was shown on cells from healthy donors and alcoholics patients. Conclusion: Obtained results allow considering lithium pyruvate as potential normothymic agents (mood stabilizer) with excellent cytoprotective properties.
Jazyk:angličtina
Vydáno: 2019
Témata:
электронный ресурс
труды учёных ТПУ
фармакология
пируват
окисление
жизнеспособность
клетки
стабилизаторы
настроение
On-line přístup:http://earchive.tpu.ru/handle/11683/64871
http://dx.doi.org/10.15171/apb.2019.035
Médium: Elektronický zdroj Kapitola
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=661907

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