Antiproliferative and Antitumour Effect of Nongenotoxic Silver Nanoparticles on Melanoma Models; Oxidative Medicine and Cellular Longevity; Vol. 2019

Antiproliferative and Antitumour Effect of Nongenotoxic Silver Nanoparticles on Melanoma Models; Oxidative Medicine and Cellular Longevity; Vol. 2019

Detalhes bibliográficos
Parent link:Oxidative Medicine and Cellular Longevity
Vol. 2019.— 2019.— [4528241, 12 p.]
Autor Corporativo: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий (ИШХБМТ)
Outros Autores: Valenzuela-Salas L. M. Lucia, Giron-Vazquez N., Garcia-Ramos J. C. Juan Carlos, Torres-Bugari O. Olivia, Gomez C. Claudia, Pestryakov A. N. Aleksey Nikolaevich, Villarreal-Gomez L. Luis, Toledano-Magana Ya. Yanis, Bogdanchikova N. Nina
Resumo:Title screen
During the last 3 decades, there has been a slow advance to obtain new treatments for malignant melanoma that improve patient survival. In this work, we present a systematic study focused on the antiproliferative and antitumour effect of AgNPs. These nanoparticles are fully characterized, are coated with polyvinylpyrrolidone (PVP), and have an average size of and a metallic silver content of 1.2% wt. Main changes on cell viability, induction of apoptosis and necrosis, and ROS generation were found on B16-F10 cells after six hours of exposure to AgNPs () or Cisplatin (). Despite the similar response for both AgNPs and Cisplatin on antiproliferative potency (cellular viability of and ) and ROS production ( and ), significantly different cell death pathways were triggered. While AgNPs induce only apoptosis (), Cisplatin induces apoptosis and necrosis at the same rate ( and , respectively). In addition to their antiproliferative activity, in vivo experiments showed that treatments of 3, 6, and 12 mg/kg of AgNPs elicit a survival rate almost 4 times higher () compared with the survival rate obtained with Cisplatin (2 mg/kg). Furthermore, the survivor mice treated with AgNPs do not show genotoxic damage determined by micronuclei frequency quantification on peripheral blood cells. These results exhibit the remarkable antitumour activity of a nongenotoxic AgNP formulation and constitute the first advance toward the application of these AgNPs for melanoma treatment, which could considerably reduce adverse effects provoked by currently applied chemotherapeutics.
Idioma:inglês
Publicado em: 2019
Assuntos:
электронный ресурс
труды учёных ТПУ
противоопухолевые свойства
наночастицы
серебро
моделирование
меланома
Acesso em linha:https://doi.org/10.1155/2019/4528241
Formato: Recurso Eletrônico Capítulo de Livro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=661244

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