Antiproliferative and Antitumour Effect of Nongenotoxic Silver Nanoparticles on Melanoma Models; Oxidative Medicine and Cellular Longevity; Vol. 2019
| Parent link: | Oxidative Medicine and Cellular Longevity Vol. 2019.— 2019.— [4528241, 12 p.] |
|---|---|
| Müşterek Yazar: | |
| Diğer Yazarlar: | , , , , , , , , |
| Özet: | Title screen During the last 3 decades, there has been a slow advance to obtain new treatments for malignant melanoma that improve patient survival. In this work, we present a systematic study focused on the antiproliferative and antitumour effect of AgNPs. These nanoparticles are fully characterized, are coated with polyvinylpyrrolidone (PVP), and have an average size of and a metallic silver content of 1.2% wt. Main changes on cell viability, induction of apoptosis and necrosis, and ROS generation were found on B16-F10 cells after six hours of exposure to AgNPs () or Cisplatin (). Despite the similar response for both AgNPs and Cisplatin on antiproliferative potency (cellular viability of and ) and ROS production ( and ), significantly different cell death pathways were triggered. While AgNPs induce only apoptosis (), Cisplatin induces apoptosis and necrosis at the same rate ( and , respectively). In addition to their antiproliferative activity, in vivo experiments showed that treatments of 3, 6, and 12 mg/kg of AgNPs elicit a survival rate almost 4 times higher () compared with the survival rate obtained with Cisplatin (2 mg/kg). Furthermore, the survivor mice treated with AgNPs do not show genotoxic damage determined by micronuclei frequency quantification on peripheral blood cells. These results exhibit the remarkable antitumour activity of a nongenotoxic AgNP formulation and constitute the first advance toward the application of these AgNPs for melanoma treatment, which could considerably reduce adverse effects provoked by currently applied chemotherapeutics. |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
2019
|
| Konular: | |
| Online Erişim: | https://doi.org/10.1155/2019/4528241 |
| Materyal Türü: | MixedMaterials Elektronik Kitap Bölümü |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=661244 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 661244 | ||
| 005 | 20250414143636.0 | ||
| 035 | |a (RuTPU)RU\TPU\network\31513 | ||
| 035 | |a RU\TPU\network\28947 | ||
| 090 | |a 661244 | ||
| 100 | |a 20191126d2019 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 102 | |a US | ||
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a Antiproliferative and Antitumour Effect of Nongenotoxic Silver Nanoparticles on Melanoma Models |f L. M. Valenzuela-Salas [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 56 tit.] | ||
| 330 | |a During the last 3 decades, there has been a slow advance to obtain new treatments for malignant melanoma that improve patient survival. In this work, we present a systematic study focused on the antiproliferative and antitumour effect of AgNPs. These nanoparticles are fully characterized, are coated with polyvinylpyrrolidone (PVP), and have an average size of and a metallic silver content of 1.2% wt. Main changes on cell viability, induction of apoptosis and necrosis, and ROS generation were found on B16-F10 cells after six hours of exposure to AgNPs () or Cisplatin (). Despite the similar response for both AgNPs and Cisplatin on antiproliferative potency (cellular viability of and ) and ROS production ( and ), significantly different cell death pathways were triggered. While AgNPs induce only apoptosis (), Cisplatin induces apoptosis and necrosis at the same rate ( and , respectively). In addition to their antiproliferative activity, in vivo experiments showed that treatments of 3, 6, and 12 mg/kg of AgNPs elicit a survival rate almost 4 times higher () compared with the survival rate obtained with Cisplatin (2 mg/kg). Furthermore, the survivor mice treated with AgNPs do not show genotoxic damage determined by micronuclei frequency quantification on peripheral blood cells. These results exhibit the remarkable antitumour activity of a nongenotoxic AgNP formulation and constitute the first advance toward the application of these AgNPs for melanoma treatment, which could considerably reduce adverse effects provoked by currently applied chemotherapeutics. | ||
| 461 | |t Oxidative Medicine and Cellular Longevity | ||
| 463 | |t Vol. 2019 |v [4528241, 12 p.] |d 2019 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a противоопухолевые свойства | |
| 610 | 1 | |a наночастицы | |
| 610 | 1 | |a серебро | |
| 610 | 1 | |a моделирование | |
| 610 | 1 | |a меланома | |
| 701 | 1 | |a Valenzuela-Salas |b L. M. |g Lucia | |
| 701 | 1 | |a Giron-Vazquez |b N. | |
| 701 | 1 | |a Garcia-Ramos |b J. C. |g Juan Carlos | |
| 701 | 1 | |a Torres-Bugari |b O. |g Olivia | |
| 701 | 1 | |a Gomez |b C. |g Claudia | |
| 701 | 1 | |a Pestryakov |b A. N. |c Chemist |c Professor of Tomsk Polytechnic University, Doctor of Chemical Science |f 1963- |g Aleksey Nikolaevich |3 (RuTPU)RU\TPU\pers\30471 |9 14796 | |
| 701 | 1 | |a Villarreal-Gomez |b L. |g Luis | |
| 701 | 1 | |a Toledano-Magana |b Ya. |g Yanis | |
| 701 | 1 | |a Bogdanchikova |b N. |g Nina | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий (ИШХБМТ) |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
| 801 | 2 | |a RU |b 63413507 |c 20191126 |g RCR | |
| 850 | |a 63413507 | ||
| 856 | 4 | |u https://doi.org/10.1155/2019/4528241 | |
| 942 | |c CF | ||