Marine Polysaccharide-Collagen Coatings on Ti6Al4V Alloy Formed by Self-Assembly; Micromachines; Vol. 10, iss. 1

Bibliographic Details
Parent link:	Micromachines Vol. 10, iss. 1.— 2019.— [68, 10 p.]
Corporate Authors:	Национальный исследовательский Томский политехнический университет Инженерная школа новых производственных технологий Научно-образовательный центр Н. М. Кижнера, Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Отделение ядерно-топливного цикла, Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий Научно-исследовательский центр "Физическое материаловедение и композитные материалы"
Other Authors:	Norris K. Karl, Mishukova O. I. Oksana Igorevna, Zykwinska A. Agata, Colliec-Jouault S. Sylvia, Sinquin C. Corinne, Koptioug A. V. Andrei, Cuenot S. Stephane, Kerns J. D. Jemma, Surmeneva M. A. Maria Alexandrovna, Surmenev R. A. Roman Anatolievich, Douglas T. E. L. Timothy
Summary:	Title screen Polysaccharides of marine origin are gaining interest as biomaterial components. Bacteria derived from deep-sea hydrothermal vents can produce sulfated exopolysaccharides (EPS), which can influence cell behavior. The use of such polysaccharides as components of organic, collagen fibril-based coatings on biomaterial surfaces remains unexplored. In this study, collagen fibril coatings enriched with HE800 and GY785 EPS derivatives were deposited on titanium alloy (Ti6Al4V) scaffolds produced by rapid prototyping and subjected to physicochemical and cell biological characterization. Coatings were formed by a self-assembly process whereby polysaccharides were added to acidic collagen molecule solution, followed by neutralization to induced self-assembly of collagen fibrils. Fibril formation resulted in collagen hydrogel formation. Hydrogels formed directly on Ti6Al4V surfaces, and fibrils adsorbed onto the surface. Scanning electron microscopy (SEM) analysis of collagen fibril coatings revealed association of polysaccharides with fibrils. Cell biological characterization revealed good cell adhesion and growth on bare Ti6Al4V surfaces, as well as coatings of collagen fibrils only and collagen fibrils enhanced with HE800 and GY785 EPS derivatives. Hence, the use of both EPS derivatives as coating components is feasible. Further work should focus on cell differentiation.
Language:	English
Published:	2019
Subjects:	труды учёных ТПУ электронный ресурс marine exopolysaccharide collagen surface modification Ti6Al4V экзополисахариды коллаген модификации поверхности
Online Access:	https://doi.org/10.3390/mi10010068
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=661108