Investigation of the Size Distribution for Diffusion-Controlled Drug Release From Drug Delivery Systems of Various Geometries; Journal of Pharmaceutical Sciences; Vol. 108, iss. 8
| Parent link: | Journal of Pharmaceutical Sciences Vol. 108, iss. 8.— 2019.— [P. 2690-2697] |
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| Hlavní autor: | |
| Korporativní autor: | |
| Další autoři: | , |
| Shrnutí: | Title screen Various drug delivery systems (DDSs) are often used in modern medicine to achieve controlled and targeted drug release. Diffusional release of drugs from DDSs is often the main mechanism, especially at early times. Generally, average dimensions of DDS are used to model the drug release, but our recent work on drug release from fibers demonstrated that taking into account diameter distribution is essential. This work systematically investigated the effect of size distribution on diffusional drug release from DDSs of various geometric forms such as membranes, fibers, and spherical particles. The investigation clearly demonstrated that the size distribution has the largest effect on the drug release profiles from spherical particles compared to other geometric forms. Published experimental data for drug release from polymer microparticles and nanoparticles were fitted, and the diffusion coefficients were determined assuming reported radius distributions. Assuming the average radius when fitting the data leads to up to 5 times underestimation of the diffusion coefficient of drug in the polymer. |
| Jazyk: | angličtina |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://doi.org/10.1016/j.xphs.2019.03.036 |
| Médium: | Elektronický zdroj Kapitola |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=660568 |
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| 200 | 1 | |a Investigation of the Size Distribution for Diffusion-Controlled Drug Release From Drug Delivery Systems of Various Geometries |f T. I. Spiridonova, S. I. Tverdokhlebov, Yu. G. Anissimov | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 330 | |a Various drug delivery systems (DDSs) are often used in modern medicine to achieve controlled and targeted drug release. Diffusional release of drugs from DDSs is often the main mechanism, especially at early times. Generally, average dimensions of DDS are used to model the drug release, but our recent work on drug release from fibers demonstrated that taking into account diameter distribution is essential. This work systematically investigated the effect of size distribution on diffusional drug release from DDSs of various geometric forms such as membranes, fibers, and spherical particles. The investigation clearly demonstrated that the size distribution has the largest effect on the drug release profiles from spherical particles compared to other geometric forms. Published experimental data for drug release from polymer microparticles and nanoparticles were fitted, and the diffusion coefficients were determined assuming reported radius distributions. Assuming the average radius when fitting the data leads to up to 5 times underestimation of the diffusion coefficient of drug in the polymer. | ||
| 461 | |t Journal of Pharmaceutical Sciences | ||
| 463 | |t Vol. 108, iss. 8 |v [P. 2690-2697] |d 2019 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a mathematical modeling | |
| 610 | 1 | |a diffusion | |
| 610 | 1 | |a drug delivery systems | |
| 610 | 1 | |a controlled drug release | |
| 610 | 1 | |a nanoparticles | |
| 610 | 1 | |a microparticles | |
| 610 | 1 | |a математическое моделирование | |
| 610 | 1 | |a диффузии | |
| 610 | 1 | |a лекарства | |
| 610 | 1 | |a наночастицы | |
| 610 | 1 | |a микрочастицы | |
| 700 | 1 | |a Spiridonova |b T. I. |c specialist in the field of material science |c Engineer of Tomsk Polytechnic University |f 1994- |g Tatjyana Igorevna |3 (RuTPU)RU\TPU\pers\43141 | |
| 701 | 1 | |a Tverdokhlebov |b S. I. |c physicist |c Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science |f 1961- |g Sergei Ivanovich |3 (RuTPU)RU\TPU\pers\30855 |9 15101 | |
| 701 | 1 | |a Anissimov |b Yu. G. |g Yuri | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Инженерная школа ядерных технологий |b Научно-образовательный центр Б. П. Вейнберга |3 (RuTPU)RU\TPU\col\23561 |
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