Dissolution testing for prolonged-release solid dosage form containing drug substances degrading in test media. Application to polymeric delivery systems of paracetamol; IOP Conference Series: Materials Science and Engineering; Vol. 511 : Perspective Materials of Constructional and Medical Purpose
| Parent link: | IOP Conference Series: Materials Science and Engineering Vol. 511 : Perspective Materials of Constructional and Medical Purpose.— 2019.— [012007, 6 p.] |
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| প্রধান লেখক: | |
| সংস্থা লেখক: | , |
| অন্যান্য লেখক: | , |
| সংক্ষিপ্ত: | Title screen Synthetic biodegradable polymers are widely used as materials for the targeted drug delivery and controlled release devices. In order to control the rate of drug release from polymer scaffolds surface ordinary dissolution testing is performed. It includes placing a device into testing media, taking probes at determined time and estimating the drug concentration. As for prolonged release the issue is the drug degradation in test media what leads to false interpretation of results. This study was focused on the investigation of paracetamol degradation in phosphate buffer saline media for three days and its effect on the results of polymeric drug delivery system dissolution test. It was shown, that relative error in the released drug concentration evaluation can rise up to 34% depending on the exposure time and the initial probe concentration. An approach of experimental results correction is proposed. |
| ভাষা: | ইংরেজি |
| প্রকাশিত: |
2019
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | http://dx.doi.org/10.1088/1757-899X/511/1/012007 http://earchive.tpu.ru/handle/11683/55439 |
| বিন্যাস: | বৈদ্যুতিক গ্রন্থের অধ্যায় |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=660532 |
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| 200 | 1 | |a Dissolution testing for prolonged-release solid dosage form containing drug substances degrading in test media. Application to polymeric delivery systems of paracetamol |f A. A. Rakina, T. I. Spiridonova, S. I. Tverdokhlebov | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 4 tit.] | ||
| 330 | |a Synthetic biodegradable polymers are widely used as materials for the targeted drug delivery and controlled release devices. In order to control the rate of drug release from polymer scaffolds surface ordinary dissolution testing is performed. It includes placing a device into testing media, taking probes at determined time and estimating the drug concentration. As for prolonged release the issue is the drug degradation in test media what leads to false interpretation of results. This study was focused on the investigation of paracetamol degradation in phosphate buffer saline media for three days and its effect on the results of polymeric drug delivery system dissolution test. It was shown, that relative error in the released drug concentration evaluation can rise up to 34% depending on the exposure time and the initial probe concentration. An approach of experimental results correction is proposed. | ||
| 461 | 1 | |0 (RuTPU)RU\TPU\network\2008 |t IOP Conference Series: Materials Science and Engineering | |
| 463 | 1 | |0 (RuTPU)RU\TPU\network\29838 |t Vol. 511 : Perspective Materials of Constructional and Medical Purpose |o International Scientific and Technical Youth Conference, 26–30 November 2018, Tomsk, Russian Federation |o [proceedings] |v [012007, 6 p.] |d 2019 | |
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| 700 | 1 | |a Rakina |b A. A. |c specialist in the field of material science |c Engineer of Tomsk Polytechnic University |f 1995- |g Apollinariya Aleksandrovna |y Tomsk |3 (RuTPU)RU\TPU\pers\43139 |9 21624 | |
| 701 | 1 | |a Spiridonova |b T. I. |c specialist in the field of material science |c Engineer of Tomsk Polytechnic University |f 1994- |g Tatjyana Igorevna |3 (RuTPU)RU\TPU\pers\43141 | |
| 701 | 1 | |a Tverdokhlebov |b S. I. |c physicist |c Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science |f 1961- |g Sergei Ivanovich |3 (RuTPU)RU\TPU\pers\30855 |9 15101 | |
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