Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia

Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia

Bibliographic Details
Parent link:Journal of Pharmacy and Pharmaceutical Sciences (JPPS)
Vol. 21.— 2018.— [P. 340-346]
Corporate Author: Национальный исследовательский Томский политехнический университет Инженерная школа неразрушающего контроля и безопасности Отделение контроля и диагностики
Other Authors: Ivanova S. A. Svetlana Aleksandrovna, Alifirova V. M. Valentina Mikhaylovna, Pozhidaev I. V. Ivan Vyacheslavovich, Freydin M. B. Maksim Borisovich, Zhukova I. A. Irina Aleksandrovna, Osmanova D. Z. Diana Zakirovn, Zhukova N. G. Nataljya Grigorjevna, Mironova Yu. A. Yuliya Aleksandrovna, Tiguntsev V. V. Vladimir Vladimirovich, Fedorenko O. Yu. Olga Yurievna, Bokhan N. A. Nikolay Aleksandrovich, Wilffert B. Bob, Loonen A. J. M. Anton
Summary:Title screen
Purpose. Parkinson's disease (PD), a common neurodegenerative disorder, is usually treated with Levodopa (L-DOPA). The use of this drug, however, is severely limited by the development of side effects of the motor system: Levodopa-induced dyskinesia (LID). The aim of this study is to investigate the association between seven COMT gene single-nucleotide polymorphisms (SNPs) and the development of LID in patients with PD. Methods. 232 Caucasian patients with PD were investigated. 212 patients with PD received Levodopa therapy. Dyskinesia was assessed with the use of the Abnormal Involuntary Movement Scale (AIMS). Genotyping was carried out on seven SNPs of the COMT gene (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) using a real-time PCR method, and blind to the clinical status of the subjects. Results. We found association between four SNPs, rs165774, rs4818, rs4633, rs4680, and LID. When the duration of disease was added as a covariate in regression analysis, however, the results did not reach statistical significance. Only the additive model for rs165774 was found to be close to be statistical significance (OR = 1.627 [0.976–2.741], permutation p = 0.057). Conclusions. The results failed to clearly support a contribution of the studied polymorphisms; this may be related to a dominant relationship with the disease duration confounding the effect on the prevalence of LID.
Language:English
Published: 2018
Subjects:
труды учёных ТПУ
электронный ресурс
гены
полиморфизм
Online Access:http://dx.doi.org/10.18433/jpps29903
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=659697

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