Mechanical, degradation and drug-release behavior of nano-grained Fe-Ag composites for biomedical applications

Mechanical, degradation and drug-release behavior of nano-grained Fe-Ag composites for biomedical applications

Detalhes bibliográficos
Parent link:Journal of the Mechanical Behavior of Biomedical Materials
Vol. 86.— 2018.— [P. 240-249]
Autor Corporativo: Национальный исследовательский Томский политехнический университет Инженерная школа новых производственных технологий Отделение материаловедения
Outros Autores: Sharipova A. R. Aliya Rashitovna, Swain S. K. Sanjaya, Gotman I. Irina, Starosvetsky D., Psakhie S. G. Sergey Grigorievich, Unger R. E. Ronald, Gutmanas E. Elazar
Resumo:Title screen
An original fabrication route of high-strength bulk Fe-5Ag and Fe-10Ag nanocomposites with enhanced degradation rate is reported. Near fully dense materials with fine nanostructures and uniform distribution of Ag nanoparticles were obtained employing high energy attrition milling of Fe-Ag2O powder blends followed by cold sintering – high pressure consolidation at ambient temperature that allowed the retention of the nanoscale structure. Annealing in hydrogen flow at 550?°C resulted in enhanced ductility without coarsening the nanostructure. The strength in compression of Fe5Ag and Fe10Ag nanocomposites was several-fold higher than the values reported for similar composites with micrometer grain size. The galvanic action of finely dispersed Ag nanoparticles greatly increased the corrosion rate and degradation kinetics of iron. Following four weeks immersion of Fe-Ag nanocomposites in saline solution, a more than 10% weight loss accompanied by less than 25% decrease in bending strength were measured. The interconnected nanoporosity of cold sintered Fe-Ag nanocomposites was utilized for incorporation of vancomycin that was gradually released upon immersion. In cell culture experiments, the Fe-Ag nanocomposites supported the attachment of osteoblast cells and exhibited no signs of cytotoxicity. The results suggest that the proposed Fe-Ag nanocomposites could be developed into attractive biodegradable load-bearing implant materials with drug delivery capability.
Режим доступа: по договору с организацией-держателем ресурса
Publicado em: 2018
Assuntos:
электронный ресурс
труды учёных ТПУ
load bearing
biodegradable
iron-silver
nanocomposite
drug release
cell culture
нанокомпозиты
подшипники
нагрузки
Acesso em linha:https://doi.org/10.1016/j.jmbbm.2018.06.037
Formato: Recurso Electrónico Capítulo de Livro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=659696

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