Mechanical, degradation and drug-release behavior of nano-grained Fe-Ag composites for biomedical applications
| Parent link: | Journal of the Mechanical Behavior of Biomedical Materials Vol. 86.— 2018.— [P. 240-249] |
|---|---|
| Corporate Author: | |
| Other Authors: | , , , , , , |
| Summary: | Title screen An original fabrication route of high-strength bulk Fe-5Ag and Fe-10Ag nanocomposites with enhanced degradation rate is reported. Near fully dense materials with fine nanostructures and uniform distribution of Ag nanoparticles were obtained employing high energy attrition milling of Fe-Ag2O powder blends followed by cold sintering – high pressure consolidation at ambient temperature that allowed the retention of the nanoscale structure. Annealing in hydrogen flow at 550?°C resulted in enhanced ductility without coarsening the nanostructure. The strength in compression of Fe5Ag and Fe10Ag nanocomposites was several-fold higher than the values reported for similar composites with micrometer grain size. The galvanic action of finely dispersed Ag nanoparticles greatly increased the corrosion rate and degradation kinetics of iron. Following four weeks immersion of Fe-Ag nanocomposites in saline solution, a more than 10% weight loss accompanied by less than 25% decrease in bending strength were measured. The interconnected nanoporosity of cold sintered Fe-Ag nanocomposites was utilized for incorporation of vancomycin that was gradually released upon immersion. In cell culture experiments, the Fe-Ag nanocomposites supported the attachment of osteoblast cells and exhibited no signs of cytotoxicity. The results suggest that the proposed Fe-Ag nanocomposites could be developed into attractive biodegradable load-bearing implant materials with drug delivery capability. Режим доступа: по договору с организацией-держателем ресурса |
| Language: | English |
| Published: |
2018
|
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.jmbbm.2018.06.037 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=659696 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 659696 | ||
| 005 | 20250326151443.0 | ||
| 035 | |a (RuTPU)RU\TPU\network\28423 | ||
| 035 | |a RU\TPU\network\4126 | ||
| 090 | |a 659696 | ||
| 100 | |a 20190320a2018 k y0engy50 ba | ||
| 101 | 0 | |a eng | |
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a Mechanical, degradation and drug-release behavior of nano-grained Fe-Ag composites for biomedical applications |f A. R. Sharipova [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 330 | |a An original fabrication route of high-strength bulk Fe-5Ag and Fe-10Ag nanocomposites with enhanced degradation rate is reported. Near fully dense materials with fine nanostructures and uniform distribution of Ag nanoparticles were obtained employing high energy attrition milling of Fe-Ag2O powder blends followed by cold sintering – high pressure consolidation at ambient temperature that allowed the retention of the nanoscale structure. Annealing in hydrogen flow at 550?°C resulted in enhanced ductility without coarsening the nanostructure. The strength in compression of Fe5Ag and Fe10Ag nanocomposites was several-fold higher than the values reported for similar composites with micrometer grain size. The galvanic action of finely dispersed Ag nanoparticles greatly increased the corrosion rate and degradation kinetics of iron. Following four weeks immersion of Fe-Ag nanocomposites in saline solution, a more than 10% weight loss accompanied by less than 25% decrease in bending strength were measured. The interconnected nanoporosity of cold sintered Fe-Ag nanocomposites was utilized for incorporation of vancomycin that was gradually released upon immersion. In cell culture experiments, the Fe-Ag nanocomposites supported the attachment of osteoblast cells and exhibited no signs of cytotoxicity. The results suggest that the proposed Fe-Ag nanocomposites could be developed into attractive biodegradable load-bearing implant materials with drug delivery capability. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Journal of the Mechanical Behavior of Biomedical Materials | ||
| 463 | |t Vol. 86 |v [P. 240-249] |d 2018 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a load bearing | |
| 610 | 1 | |a biodegradable | |
| 610 | 1 | |a iron-silver | |
| 610 | 1 | |a nanocomposite | |
| 610 | 1 | |a drug release | |
| 610 | 1 | |a cell culture | |
| 610 | 1 | |a нанокомпозиты | |
| 610 | 1 | |a подшипники | |
| 610 | 1 | |a нагрузки | |
| 701 | 1 | |a Sharipova |b A. R. |g Aliya Rashitovna | |
| 701 | 1 | |a Swain |b S. K. |g Sanjaya | |
| 701 | 1 | |a Gotman |b I. |c Specialist in the field of material science |c Leading researcher of Tomsk Polytechnic University |f 1957- |g Irina |3 (RuTPU)RU\TPU\pers\37811 | |
| 701 | 1 | |a Starosvetsky |b D. | |
| 701 | 1 | |a Psakhie |b S. G. |c physicist |c head of laboratory, Advisor to the rector, head of Department, Tomsk Polytechnic University, doctor of physico-mathematical Sciences |f 1952-2018 |g Sergey Grigorievich |3 (RuTPU)RU\TPU\pers\33038 | |
| 701 | 1 | |a Unger |b R. E. |g Ronald | |
| 701 | 1 | |a Gutmanas |b E. |g Elazar | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Инженерная школа новых производственных технологий |b Отделение материаловедения |3 (RuTPU)RU\TPU\col\23508 |
| 801 | 2 | |a RU |b 63413507 |c 20190320 |g RCR | |
| 856 | 4 | |u https://doi.org/10.1016/j.jmbbm.2018.06.037 | |
| 942 | |c CF | ||