Antibacterial Action of Mixed-ligand Imidazole - Phenanthroline Copper Complex

Մատենագիտական մանրամասներ
Parent link:	Anti-Infective Agents Vol. 16, iss. 2.— 2018.— [P. 100-103]
Հիմնական հեղինակ:	Plotnikov E. V. Evgeny Vladimirovich
Համատեղ հեղինակներ:	Национальный исследовательский Томский политехнический университет Инженерная школа природных ресурсов Отделение химической инженерии, Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий (ИШХБМТ)
Այլ հեղինակներ:	Plotnikov V. M. Vladimir Mikhaylovich
Ամփոփում:	Title screen Background: Multidrug Resistance (MDR) of microorganisms is the biggest pharmacological challenge, despite plenty of modern antibiotics. Obviously, new classes of antimicrobial drugs against MDR pathogens need to be developed. Objective: This work aimed to investigate the antibacterial properties of the novel copper-based complex - bisimidazoles - (1,10) phenanthroline cuprum (II) dichloride - [CuPhenIm2]Cl2. Material & Methods: The complex - bisimidazoles-(1,10)phenanthroline cuprum (II) dichloride - [Cu- Phen-Im2]Cl2 was synthetized for the experiment. The structure was identified by elemental analysis and IR spectroscopy. The antibacterial properties of the copper complex were investigated by agar diffusion and serial dilution methods with the following bacteria strains Staphylococcus haemolyticus (ATCC 29970), Staphylococcus aureus (ATCC 25923), Proteus vulgaris (ATCC 13315), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Mycobacterium bovis (Valle). Antituberculosis activity test included evaluation of bacterial growth on Lowenstein Jensen media with a serial dilution of copper complex, within an observation period of 90 days. Results: The prospect copper complex showed significant antibacterial activity. The most susceptible to copper action were strains of S.haemolyticus and S.aureus. The bisimidazoles - (1,10) phenanthroline cuprum (II) dichloride revealed moderate bactericidal action against Mycobacteria bovis. Conclusion: Most of the tested bacterial pathogens were highly susceptible to the novel copper substance. A detailed assessment of the biological action in in vivo is further required. Режим доступа: по договору с организацией-держателем ресурса
Հրապարակվել է:	2018
Խորագրեր:	электронный ресурс труды учёных ТПУ copper-based complex phenanthroline imidazoles antibacterial drug staphylococcus mycobacterium bovis фенантролины имидазолы антибактериальные препараты стафилококки
Առցանց հասանելիություն:	http://dx.doi.org/10.2174/2211352516666180531075622
Ձևաչափ:	Էլեկտրոնային Գրքի գլուխ
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=659420