Imbalance in the glutathione system in Opisthorchis felineus infected liver promotes hepatic fibrosis; International Journal of Nanomedicine; Vol. 192

Imbalance in the glutathione system in Opisthorchis felineus infected liver promotes hepatic fibrosis; International Journal of Nanomedicine; Vol. 192

Bibliographische Detailangaben
Parent link:International Journal of Nanomedicine
Vol. 192.— 2019.— [P. 41-48]
Körperschaft: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий (ИШХБМТ)
Weitere Verfasser: Perina E. A. Ekaterina Aleksandrovna, Ivanov V. V. Vladimir Vladimirovich, Pershina A. G. Aleksandra Gennadievna, Perekucha N. A. Nataljya Andreevna, Ogorodova L. M. Ludmila Mikhaylovna
Zusammenfassung:Title screen
Although data on oxidative stress during liver fluke infection have been previously presented, a comprehensive study of the glutathione system that plays a crucial role in scavenging of reactive oxygen species (ROS) and detoxification of primary and secondary oxidation products has not been addressed yet. In the present study, the hepatic glutathione system was investigated in a hamster model of experimental opisthorchiasis infection. It was shown that chronic oxidative stress in an Opisthorchis felineus infected liver, evidenced by abundant hydroperoxide accumulation, leads to strong imbalance in the hepatic glutathione system, namely the depletion of reduced form of glutathione (GSH), lowering of the GSH/GSSG ratio, and a decrease in the glutathione peroxidase and glyoxalase 1 activity. O. felineus infection provokes hepatocellular damage that results in the progression of liver fibrosis, accompanied by an increase in collagen deposition in the hepatic tissue. Modulation of hepatic GSH levels in the O. felineus infected liver through N-acetylcysteine (NAC) or l-buthionine-S, R-sulfoxinine (BSO) treatments lead to changes in expression and activity of glutathione S-transferase and glyoxalase I as well as markedly decreases or increases collagen content in the O. felineus infected liver and the severity of liver fibrosis, respectively. Thus, the glutathione system can be considered as a target for liver protection from O. felineus-induced injury.
Режим доступа: по договору с организацией-держателем ресурса
Sprache:Englisch
Veröffentlicht: 2019
Schlagworte:
труды учёных ТПУ
электронный ресурс
qlutathione system
liver fibrosis
oxidative stress
opisthorchis felineus
l-buthionine-S
R-sulfoxinine
N-acetylcysteine
глутатионы
Online-Zugang:https://doi.org/10.1016/j.actatropica.2019.01.017
Format: Elektronisch Buchkapitel
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=659327

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