The determination of enantiomer composition of 1‐((3‐chlorophenyl)‐(phenyl)methyl) amine and 1‐((3‐chlorophenyl)(phenyl)‐methyl) urea (Galodif) by NMR spectroscopy, chiral HPLC, and polarimetry; Chirality; Vol. 30, iss. 10

The determination of enantiomer composition of 1‐((3‐chlorophenyl)‐(phenyl)methyl) amine and 1‐((3‐chlorophenyl)(phenyl)‐methyl) urea (Galodif) by NMR spectroscopy, chiral HPLC, and polarimetry; Chirality; Vol. 30, iss. 10

Manylion Llyfryddiaeth
Parent link:	Chirality.— , 1999- Vol. 30, iss. 10.— 2018.— [P.1135-1143]
Awdur Corfforaethol:	Национальный исследовательский Томский политехнический университет Инженерная школа новых производственных технологий Научно-образовательный центр Н. М. Кижнера
Awduron Eraill:	Kuksenok V. Yu. Vera Yurievna, Shtrykova V. V. Viktoriya Viktorovna, Filimonov V. D. Viktor Dmitrievich, Druganov A. G., Bondarev A. A. Aleksandr Aleksandrovich, Stankevich K. S. Ksenia Sergeevna
Crynodeb:	Title screen For the first time, a method for enantiomer resolution of the anticonvulsant Galodif (1‐((3‐chlorophenyl)(phenyl)methyl) urea) by chiral HPLC was developed, whereas the enantiomeric composition of 1‐((3‐chlorophenyl)(phenyl)methyl) amine-precursor in Galodif synthesis-cannot be resolved by this method. However, starting 1‐((3‐chlorophenyl)(phenyl)methyl) amine quantitatively forms diastereomeric N‐((3‐chlorophenyl)(phenyl)methyl)‐1‐camphorsulfonamides in reaction with chiral (1R)‐(+)‐ or (1S)‐(−)‐camphor‐10‐sulfonyl chlorides. The diastereomeric ratio of obtained camphorsulfonamides can be easily determined by NMR 1H and 13C spectroscopy. The DFT calculations of specific rotation of Galodif enantiomers showed good agreement with experimental data. The absolute configuration of enantiomers was proposed for the first time. Режим доступа: по договору с организацией-держателем ресурса
Iaith:	Saesneg
Cyhoeddwyd:	2018
Pynciau:	электронный ресурс труды учёных ТПУ anticonvulsants chiral analysis chiral HPLC Galodif NMR spectroscopy polarimetry specificrotation calculations спектрометрия поляриметрия хиральность
Mynediad Ar-lein:	https://doi.org/10.1002/chir.23005
Fformat:	Electronig Pennod Llyfr
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=659009

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