Folic acid-chitosan-alginate nanocomplexes for multiple delivery of chemotherapeutic agents; Journal of Drug Delivery Science and Technology; Vol. 47

Folic acid-chitosan-alginate nanocomplexes for multiple delivery of chemotherapeutic agents; Journal of Drug Delivery Science and Technology; Vol. 47

Bibliographic Details
Parent link:Journal of Drug Delivery Science and Technology: Scientific Journal
Vol. 47.— 2018.— [P. 67-76]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий (ИШХБМТ)
Other Authors: Di Martino A. Antonio, Trusova M. E. Marina Evgenievna, Postnikov P. S. Pavel Sergeevich, Sedlarik V. Vladimir
Summary:Title screen
A major challenge faced by researchers involved in the sphere of drug delivery is the development of innovative multidrug delivery systems. Herein, experimentation focused on preparing nanocomplexes based on chitosan and alginic acid with the purpose of allocating a combination of chemotherapeutic drugs, improving their efficacy and reducing dosage. In order to enhance targeting, conjugation with folic acid was performed. The prepared carriers exhibited a spherical shape with a diameter in the range 70–120?nm, a ?-potential between 30 and 35?mV with good stability in human serum, and low hemolytic activity of up to 100??g/mL. Over 800??g of drugs per mg of carrier were loaded and released, displaying a pH-dependent trend with no physical, chemical and biological interferences, which benefited from the advantage of having full control over the given release of drug. In vitro studies performed on human epithelial cervix carcinoma cells and mouse fibroblast cells clearly demonstrated that said dual-loaded complexes showed greater cytotoxicity than single-loaded and free-drug formulations. The viability of the cells decreased, thereby confirming the primary role played by the targeting molecule.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2018
Subjects:
электронный ресурс
труды учёных ТПУ
полисахариды
фолиевая кислота
терапия
Online Access:https://doi.org/10.1016/j.jddst.2018.06.020
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=658832

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