Two-Dimensional Al Hydroxide Interaction with Cancerous Cell Membrane Building Units: Complexed Free Energy and Orientation Analysis; AIP Conference Proceedings; Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17)

Two-Dimensional Al Hydroxide Interaction with Cancerous Cell Membrane Building Units: Complexed Free Energy and Orientation Analysis; AIP Conference Proceedings; Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17)

التفاصيل البيبلوغرافية
Parent link:AIP Conference Proceedings
Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17).— 2017.— [020076, 5 p.]
المؤلف الرئيسي: Tsukanov A. A. Aleksey Alekseevich
مؤلف مشترك: Национальный исследовательский Томский политехнический университет Инженерная школа новых производственных технологий Отделение материаловедения
مؤلفون آخرون: Psakhie S. G. Sergey Grigorievich
الملخص:Title screen
The application of hierarchical nanoparticles based on metal hydroxides in biomedicine, including anticancer therapy and medical imaging, is a rapidly developing field. Low-dimensional aluminum oxyhydroxide nanomaterials (AlOOH-NM) are quite promising base to develop hybrid theranostic nano-agents with core-shell architecture, which is determined by AlOOH-NMs physicochemical properties such as: large specific surface area, pH-dependent charge, amphoteric behavior, high surface density of polar groups capable to form non-covalent bonds, low or null cytotoxicity and biocompatibility. Characterization of the system behavior within interface between NM and plasmatic membrane is crucial for the understanding of nano-agent-cell interaction. In the present work the complex in silico study including the free energy estimation and orientation analysis of phosphatidylcholine (POPC) and phosphatidylethanolamine (POPE) lipids interacting with AlOOH nanosheet was conducted to understand the effect of such nanomaterial on cancerous cell plasmatic membrane.
Режим доступа: по договору с организацией-держателем ресурса
اللغة:الإنجليزية
منشور في: 2017
الموضوعات:
электронный ресурс
труды учёных ТПУ
гидроксид алюминия
рак
наночастицы
биомедицина
противоопухолевая терапия
медицинская визуализация
физико-химические свойства
цитотоксичность
биосовместимость
раковые клетки
الوصول للمادة أونلاين:https://doi.org/10.1063/1.5001655
http://earchive.tpu.ru/handle/11683/46891
التنسيق: الكتروني فصل الكتاب
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=657748

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