Nuclear Medicine Imaging of Locally Advanced Laryngeal and Hypopharyngeal Cancer; AIP Conference Proceedings; Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17)

Nuclear Medicine Imaging of Locally Advanced Laryngeal and Hypopharyngeal Cancer; AIP Conference Proceedings; Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17)

Dades bibliogràfiques
Parent link:AIP Conference Proceedings
Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17).— 2017.— [020048, 6 p.]
Altres autors: Medvedeva А. А. Anna Aleksandrovna, Chernov V. I. Vladimir Ivanovich, Zelchan (Zeltchan) R. V. Roman Vladimirovich, Sinilkin I. G. Ivan Gennadjevich, Bragina O. D. Olga Dmitrievna, Chijevskaya S., Choynzonov E., Goldberg A.
Sumari:Title screen
The diagnostic capabilities of nuclear medicine imaging in the detection and assessment of the spread of laryngeal/hypopharyngeal cancer were studied. A total of 40 patients with histologically verified laryngeal and hypopharyngeal cancer and 20 patients with benign laryngeal lesions were included into the study. Submucosal injections of {99m}Tc-MIBI and {99m}Tc-Alotech were made around the tumor. Single photon emission computed tomography (SPECT) was performed 20 minutes after the injection of {99m}Tc-MIBI. Sentinel lymph nodes (SLNs) were detected in 26 patients. In 18 hours after the injection of {99m}Tc-Alotech, SPECT was performed. In 24 hours after the injection of {99m}Tc-Alotech, intraoperative SLN detection was performed using Gamma Finder II. SPECT with {99m}Tc-MIBI revealed laryngeal and hypopharyngeal tumors in 38 of the 40 patients. The {99m}Tc-MIBI uptake in metastatic lymph nodes was visualized in 2 (17%) of the 12 patients. Twenty eight SLNs were detected by SPECT and 31 SLNs were identified using the intraoperative gamma probe. The percentage of {99m}Tc-Alotech in the SLN was 5-10% of the radioactivity in the injection site by SPECT and 18-33% by intraoperative gamma probe detection. Thus, SPECT with {99m}Tc-MIBI is an effective tool for the diagnosis of laryngeal/hypopharyngeal cancer. The sensitivity, specificity and accuracy of this technique were 95%, 80% and 92%, respectively. The use of {99m}Tc-Alotech for the detection of SLNs in patients with laryngeal/hypopharyngeal cancer is characterized by 92.8% sensitivity.
Режим доступа: по договору с организацией-держателем ресурса
Idioma:anglès
Publicat: 2017
Matèries:
электронный ресурс
труды учёных ТПУ
ядерная медицина
визуализация
рак
гортань
диагностические возможности
выживаемость
Accés en línia:https://doi.org/10.1063/1.5001627
http://earchive.tpu.ru/handle/11683/46883
Format: MixedMaterials Electrònic Capítol de llibre
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=657737

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