Lithium ascorbate as a protector of human blood biomolecules under ethanol impact; National Journal of Physiology, Pharmacy and Pharmacology; Vol. 8, iss. 1
| Parent link: | National Journal of Physiology, Pharmacy and Pharmacology Vol. 8, iss. 1.— 2018.— [P. 82-86] |
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| مؤلف مشترك: | |
| مؤلفون آخرون: | , , , |
| الملخص: | Title screen Background: Alcoholism is an acute social problem worldwide for negative impact on health. This problem is closelyassociated with social stress and drinking traditions. Previously, it was established exhaustion of blood antioxidant inalcoholism patients. It requires development and investigation of substances with protective properties under ethanol impact,on both cells and biomolecules. Aims and Objectives: Lithium salts are widely used in medicine as mood stabilizers formental pathologies, including alcoholism. In this work, we investigate lithium ascorbate for the protection of humanblood plasma lipids and proteins under ethanol impact. Materials and Methods: Well-known antioxidants - carnosineand ascorbic acid - were used as reference drugs. Heparinized venous blood was used as an experimental substrate. Theethanol and tested substances in the form of water (physiological)solutions were added to blood in vitro. Protection effectswere measured and estimated as concentrations of carbonyls proteins and products of lipid peroxidation in blood plasma.Results: It was shown similar protective action of lithium ascorbate and carnosine on human plasma biomolecules againstdamaging action of ethanol. No protective effect revealed for ascorbic acid. Conclusion: Lithium ascorbate and carnosinewere proved to possess the protection effects for blood lipids and proteins under ethanol impact. Normothymic and bloodprotectiveproperties are desirable for psychotropic drugs, and thus, lithium salts could be considered as prospective agentsin the treatment of addictions and other pathologies associated with oxidative stress. |
| اللغة: | الإنجليزية |
| منشور في: |
2018
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.5455/njppp.2018.8.0935812102017 |
| التنسيق: | الكتروني فصل الكتاب |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=657603 |