Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Bibliographic Details
Parent link:Journal of Leukocyte Biology
Vol. 101, iss. 6.— 2017.— [P. 1361-1371]
Corporate Author: Национальный исследовательский Томский политехнический университет (ТПУ) Институт физики высоких технологий (ИФВТ) Кафедра биотехнологии и органической химии (БИОХ)
Other Authors: Ozek G. Gulmira, Shchepetkin I. A. Igor Alexandrovitch, Utegenova G. A. Gulzhakhan A., Kirpotina L. N. Liliya Nikolaevna, Spencer A. R. Andrei, Ozek T. Temel, Baser Kemal Husnu Can, Abidkulova K. T. Karime, Kushnarenko S. V. Svetlana Veniaminovna, Khlebnikov A. I. Andrey Ivanovich, Damron D. S. Derek, Quinn M. T. Quinn
Summary:Title screen
Essential oil extracts from Ferula iliensis have been used traditionally in Kazakhstan for treatment of inflammation and other illnesses. Because little is known about the biologic activity of these essential oils that contributes to their therapeutic properties, we analyzed their chemical composition and evaluated their phagocyte immunomodulatory activity. The main components of the extracted essential oils were (E)-propenyl sec-butyl disulfide (15.7–39.4%) and (Z)-propenyl sec-butyl disulfide (23.4–45.0%). Ferula essential oils stimulated [Ca2+]i mobilization in human neutrophils and activated ROS production in human neutrophils and murine bone marrow phagocytes. Activation of human neutrophil [Ca2+]i flux by Ferula essential oils was dose-dependently inhibited by capsazepine, a TRPV1 channel antagonist, indicating that TRPV1 channels mediate this response. Furthermore, Ferula essential oils stimulated Ca2+ influx in TRPV1 channel–transfected HEK293 cells and desensitized the capsaicin-induced response in these cells. Additional molecular modeling with known TRPV1 channel agonists suggested that the active component is likely to be (Z)-propenyl sec-butyl disulfide. Our results provide a cellular and molecular basis to explain at least part of the beneficial therapeutic properties of FEOs.
Режим доступа: по договору с организацией-держателем ресурса
Published: 2017
Subjects:
труды учёных ТПУ
электронный ресурс
химический состав
фагоциты
Online Access:https://doi.org/10.1189/jlb.3A1216-518RR
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=657097

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