Deep-penetrating photodynamic therapy with KillerRed mediated by upconversion nanoparticles; Acta Biomaterialia; Vol. 51

Deep-penetrating photodynamic therapy with KillerRed mediated by upconversion nanoparticles

Xehetasun bibliografikoak
Parent link:Acta Biomaterialia
Vol. 51.— 2017.— [P. 461-470]
Erakunde egilea: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Лаборатория радиационного контроля № 31 (Лаборатория РК № 31)
Beste egile batzuk: Liuen Liang, Yiqing Lu, Run Zhang, Care A. Andrew, Ortega T. A. Tiago Almeida, Deev S. M. Sergey Mikhaylovich, Qian Yi., Zvyagin A. V. Andrey V.
Gaia:Title screen
The fluorescent protein KillerRed, a new type of biological photosensitizer, is considered as a promising substitute for current synthetic photosensitizes used in photodynamic therapy (PDT). However, broad application of this photosensitiser in treating deep-seated lesions is challenging due to the limited tissue penetration of the excitation light with the wavelength falling in the visible spectral range. To overcome this challenge, we employ upconversion nanoparticles (UCNPs) that are able to convert deep-penetrating near infrared (NIR) light to green light to excite KillerRed locally, followed by the generation of reactive oxygen species (ROS) to kill tumour cells under centimetre-thick tissue. The photosensitizing bio-nanohybrids, KillerRed-UCNPs, are fabricated through covalent conjugation of KillerRed and UCNPs. The resulting KillerRed-UCNPs exhibit excellent colloidal stability in biological buffers and low cytotoxicity in the dark. Cross-comparison between the conventional KillerRed and UCNP-mediated KillerRed PDT demonstrated superiority of KillerRed-UCNPs photosensitizing by NIR irradiation, manifested by the fact that ?70% PDT efficacy was achieved at 1-cm tissue depth, whereas that of the conventional KillerRed dropped to ~7%.
Hizkuntza:ingelesa
Argitaratua: 2017
Gaiak:
электронный ресурс
труды учёных ТПУ
фотодинамическая терапия
фотосенсибилизаторы
белок
наночастицы
передача энергии
Sarrera elektronikoa:https://doi.org/10.1016/j.actbio.2017.01.004
Formatua: Baliabide elektronikoa Liburu kapitulua
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=656696

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