Surface modification of biomaterials based on high-molecular polylactic acid and their effect on inflammatory reactions of primary human monocyte-derived macrophages: Perspective for personalized therapy
| Parent link: | Materials Science and Engineering: C.— , 1993- Vol. 51.— 2015.— [P. 117-126] |
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| Corporate Authors: | , |
| Other Authors: | , , , , , , |
| Summary: | Title screen Polylactic acid (PLA) based implants can cause inflammatory complications. Macrophages are key innate immune cells that control inflammation. To provide higher biocompatibility of PLA-based implants with local innate immune cells their surface properties have to be improved. In our study surface modification technique for high-molecular PLA (MW = 1,646,600 g/mol) based biomaterials was originally developed and successfully applied. Optimal modification conditions were determined. Treatment of PLA films with toluene/ethanol = 3/7 mixture for 10 min with subsequent exposure in 0.001 M brilliant green dye (BGD) solution allows to entrap approximately 10? 9 mol/cm2 model biomolecules. The modified PLA film surface was characterized by optical microscopy, SERS, FT-IR, UV and TG/DTA/DSC analysis. Режим доступа: по договору с организацией-держателем ресурса |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.msec.2015.02.047 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=656642 |
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| 200 | 1 | |a Surface modification of biomaterials based on high-molecular polylactic acid and their effect on inflammatory reactions of primary human monocyte-derived macrophages: Perspective for personalized therapy |f K. S. Stankevich [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: p. 126 (53 tit.)] | ||
| 330 | |a Polylactic acid (PLA) based implants can cause inflammatory complications. Macrophages are key innate immune cells that control inflammation. To provide higher biocompatibility of PLA-based implants with local innate immune cells their surface properties have to be improved. In our study surface modification technique for high-molecular PLA (MW = 1,646,600 g/mol) based biomaterials was originally developed and successfully applied. Optimal modification conditions were determined. Treatment of PLA films with toluene/ethanol = 3/7 mixture for 10 min with subsequent exposure in 0.001 M brilliant green dye (BGD) solution allows to entrap approximately 10? 9 mol/cm2 model biomolecules. The modified PLA film surface was characterized by optical microscopy, SERS, FT-IR, UV and TG/DTA/DSC analysis. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Materials Science and Engineering: C |d 1993- | ||
| 463 | |t Vol. 51 |v [P. 117-126] |d 2015 | ||
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| 701 | 1 | |a Gudima |b A. |g Aleksandru | |
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| 701 | 1 | |a Mamontova |b E. M. |g Evgeniya Mikhaylovna | |
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