Surface modification of biomaterials based on high-molecular polylactic acid and their effect on inflammatory reactions of primary human monocyte-derived macrophages: Perspective for personalized therapy

Surface modification of biomaterials based on high-molecular polylactic acid and their effect on inflammatory reactions of primary human monocyte-derived macrophages: Perspective for personalized therapy

Bibliographic Details
Parent link:Materials Science and Engineering: C.— , 1993-
Vol. 51.— 2015.— [P. 117-126]
Corporate Authors: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Кафедра теоретической и экспериментальной физики (ТиЭФ), Национальный исследовательский Томский политехнический университет (ТПУ) Институт физики высоких технологий (ИФВТ) Кафедра биотехнологии и органической химии (БИОХ)
Other Authors: Stankevich K. S. Ksenia Sergeevna, Gudima A. Aleksandru, Filimonov V. D. Viktor Dmitrievich, Kluter H. Haralg, Mamontova E. M. Evgeniya Mikhaylovna, Tverdokhlebov S. I. Sergei Ivanovich, Kzhyshkowska J. Julia
Summary:Title screen
Polylactic acid (PLA) based implants can cause inflammatory complications. Macrophages are key innate immune cells that control inflammation. To provide higher biocompatibility of PLA-based implants with local innate immune cells their surface properties have to be improved. In our study surface modification technique for high-molecular PLA (MW = 1,646,600 g/mol) based biomaterials was originally developed and successfully applied. Optimal modification conditions were determined. Treatment of PLA films with toluene/ethanol = 3/7 mixture for 10 min with subsequent exposure in 0.001 M brilliant green dye (BGD) solution allows to entrap approximately 10? 9 mol/cm2 model biomolecules. The modified PLA film surface was characterized by optical microscopy, SERS, FT-IR, UV and TG/DTA/DSC analysis.
Режим доступа: по договору с организацией-держателем ресурса
Published: 2015
Subjects:
электронный ресурс
труды учёных ТПУ
полимолочная кислота
поверхность
биосовместимость
моноциты
макрофаги
цитокины
Online Access:https://doi.org/10.1016/j.msec.2015.02.047
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=656642
Description
Summary:Title screen
Polylactic acid (PLA) based implants can cause inflammatory complications. Macrophages are key innate immune cells that control inflammation. To provide higher biocompatibility of PLA-based implants with local innate immune cells their surface properties have to be improved. In our study surface modification technique for high-molecular PLA (MW = 1,646,600 g/mol) based biomaterials was originally developed and successfully applied. Optimal modification conditions were determined. Treatment of PLA films with toluene/ethanol = 3/7 mixture for 10 min with subsequent exposure in 0.001 M brilliant green dye (BGD) solution allows to entrap approximately 10? 9 mol/cm2 model biomolecules. The modified PLA film surface was characterized by optical microscopy, SERS, FT-IR, UV and TG/DTA/DSC analysis.
Режим доступа: по договору с организацией-держателем ресурса
DOI:10.1016/j.msec.2015.02.047

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