Polylactic Acid Sealed Polyelectrolyte Multilayer Microchambers for Entrapment of Salts and Small Hydrophilic Molecules Precipitates; ACS Applied Materials & Interfaces; Vol. 9, iss. 19

Polylactic Acid Sealed Polyelectrolyte Multilayer Microchambers for Entrapment of Salts and Small Hydrophilic Molecules Precipitates; ACS Applied Materials & Interfaces; Vol. 9, iss. 19

Dettagli Bibliografici
Parent link:ACS Applied Materials & Interfaces
Vol. 9, iss. 19.— 2017.— [P. 16536-16545]
Ente Autore: Национальный исследовательский Томский политехнический университет (ТПУ) Управление проректора по научной работе и инновациям (НРиИ) Центр RASA в Томске Лаборатория изучения механизмов нейропротекции (Лаб. ИМН)
Altri autori: Gai M. Meiyu, Frueh J. С. Johannes Christoph, Kudryavtseva V. L. Valeriya Lvovna, Yashchenok A. M. Alexey, Sukhorukov G. B. Gleb Borisovich
Riassunto:Title screen
Efficient depot systems for entrapment and storage of small water-soluble molecules are of high demand for wide variety of applications ranging from implant based drug delivery in medicine and catalysis in chemical processes to anticorrosive systems in industry where surface-mediated active component delivery is required on a time and site specific manner. This work reports the fabrication of individually sealed hollow-structured polyelectrolyte multilayer (PEM) microchamber arrays based on layer-by-layer self-assembly as scaffolds and microcontact printing. These PEM chambers are composed out of biocompatible polyelectrolytes and sealed by a monolayer of hydrophobic biocompatible and biodegradable polylactic acid (PLA). Coating the chambers with hydrophobic PLA allows for entrapment of a microair-bubble in each chamber that seals and hence drastically reduces the PEM permeability. PLA@PEM microchambers are proven to enable prolonged subaqueous storage of small hydrophilic salts and molecules such as crystalline NaCl, doxicycline, and fluorescent dye rhodamine B. The presented microchambers are able to entrap air bubbles and demonstrate a novel strategy for entrapment, storage, and protection of micropackaged water-soluble substances in precipitated form. These chambers allow triggered release as demonstrated by ultrasound responsiveness of the chambers. Low-frequency ultrasound exposure is utilized for microchamber opening and payload release.
Режим доступа: по договору с организацией-держателем ресурса
Lingua:inglese
Pubblicazione: 2017
Soggetti:
электронный ресурс
труды учёных ТПУ
воздушные пузырьки
контролируемые атмосферы
гидрофобизация
полиэлектролиты
стимулы
Accesso online:https://doi.org/10.1021/acsami.7b03451
Natura: Elettronico Capitolo di libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=655926

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