Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3; Bulletin of Experimental Biology and Medicine; Vol. 161, iss. 3

Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3; Bulletin of Experimental Biology and Medicine; Vol. 161, iss. 3

Bibliografiska uppgifter
Parent link:Bulletin of Experimental Biology and Medicine
Vol. 161, iss. 3.— 2016.— [P. 371-373]
Institutionell upphovsman: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Лаборатория радиационного контроля № 31 (Лаборатория РК № 31)
Övriga upphovsmän: Varlamova N. V. Natalya Valeryevna, Churin A. A. Aleksey Aleksandrovich, Fomina T. I. Tatjyana Ivanovna, Ermolaeva L. A. Lyubov Aleksandrovna, Vetoshkina T. V. Tatjyana Vladimirovna, Dubskaya T. Yu. Tatjyana Yurjevna, Lamzina T. Yu. Tatjyana Yurjevna, Fedorova E. P. Elena Pavlovna, Neupokoeva O. V. Oksana Vladimirovna, Larionova L. A. Lyudmila Aleksandrovna, Skuridin V. S. Viktor Sergeyevich, Nesterov E. A. Evgeny Alexandrovich, Chernov V. I. Vladimir Ivanovich
Sammanfattning:Title screen
We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.
Режим доступа: по договору с организацией-держателем ресурса
Språk:engelska
Publicerad: 2016
Ämnen:
электронный ресурс
труды учёных ТПУ
радиофармацевтика
токсичность
субхроническая токсичность
доклинические исследования
Länkar:https://doi.org/10.1007/s10517-016-3416-0
Materialtyp: Elektronisk Bokavsnitt
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=655916

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