Fabrication of PLA/CaCO3 hybrid micro-particles as carriers for water-soluble bioactive molecules

Fabrication of PLA/CaCO3 hybrid micro-particles as carriers for water-soluble bioactive molecules

Dettagli Bibliografici
Parent link:Colloids and Surfaces B: Biointerfaces
Vol. 157.— 2017.— [P. 481-489]
Enti autori: Национальный исследовательский Томский политехнический университет (ТПУ) Управление проректора по научной работе и инновациям (НРиИ) Центр RASA в Томске Лаборатория изучения механизмов нейропротекции (Лаб. ИМН), Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Кафедра экспериментальной физики (ЭФ)
Altri autori: Kudryavtseva V. L. Valeriya Lvovna, Zhao L. Li, Tverdokhlebov S. I. Sergei Ivanovich, Sukhorukov G. B.
Riassunto:Title screen
We propose the use of polylactic acid/calcium carbonate (PLA/CaCO3) hybrid micro-particles for achieving improved encapsulation of water-soluble substances. Biodegradable porous CaCO3 microparticles can be loaded with wide range of bioactive substance. Thus, the formation of hydrophobic polymeric shell on surface of these loaded microparticles results on encapsulation and, hence, sealing internal cargo and preventing their release in aqueous media. In this study, to encapsulate proteins, we explore the solid-in-oil-in-water emulsion method for fabricating core/shell PLA/CaCO3 systems. We used CaCO3 particles as a protective core for encapsulated bovine serum albumin, which served as a model protein system. We prepared a PLA coating using dichloromethane as an organic solvent and polyvinyl alcohol as a surfactant for emulsification; in addition, we varied experimental parameters such as surfactant concentration and polymer-to-CaCO3 ratio to determine their effect on particle-size distribution, encapsulation efficiency and capsule permeability. The results show that the particle size decreased and the size distribution narrowed as the surfactant concentration increased in the external aqueous phase. In addition, when the CaCO3/PLA mass ratio dropped below 0.8, the hybrid micro-particles were more likely to resist treatment by ethylenediaminetetraacetic acid and thus retained their bioactive cargos within the polymer-coated micro-particles.
Режим доступа: по договору с организацией-держателем ресурса
Pubblicazione: 2017
Soggetti:
электронный ресурс
труды учёных ТПУ
биодеградируемые полимеры
микрокапсулы
карбонат кальция
Accesso online:https://doi.org/10.1016/j.colsurfb.2017.06.011
Natura: Elettronico Capitolo di libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=655873

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