Organic-inorganic hybrid nanoparticles controlled delivery system for anticancer drugs; Iranian Journal of Radiology; Vol. 526, iss. 1-2

Detaylı Bibliyografya
Parent link:	Iranian Journal of Radiology Vol. 526, iss. 1-2.— 2017.— [P. 380-390]
Kurumsal yazarlar:	Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Кафедра прикладной физики (№ 12) (ПФ), Национальный исследовательский Томский политехнический университет (ТПУ) Институт природных ресурсов (ИПР) Кафедра технологии органических веществ и полимерных материалов (ТОВПМ), Национальный исследовательский Томский политехнический университет (ТПУ) Институт физики высоких технологий (ИФВТ) Кафедра биотехнологии и органической химии (БИОХ)
Diğer Yazarlar:	Di Martino A. Antonio, Guselnikova O. A. Olga Andreevna, Trusova M. E. Marina Evgenievna, Postnikov P. S. Pavel Sergeevich, Sedlarik V. Vladimir
Özet:	Title screen The use of organic-inorganic hybrid nanocarriers for controlled release of anticancer drugs has been gained a great interest, in particular, to improve the selectivity and efficacy of the drugs. In this study, iron oxide nanoparticles were prepared then surface modified via diazonium chemistry and coated with chitosan, and its derivative chitosan-grafted polylactic acid. The purpose was to increase the stability of the nanoparticles in physiological solution, heighten drug-loading capacity, prolong the release, reduce the initial burst effect and improve in vitro cytotoxicity of the model drug doxorubicin. The materials were characterized by DLS, ?-potential, SEM, TGA, magnetization curves and release kinetics studies. Results confirmed the spherical shape, the presence of the coat and the advantages of using chitosan, particularly its amphiphilic derivative, as a coating agent, thereby surpassing the qualities of simple iron oxide nanoparticles. The coated nanoparticles exhibited great stability and high encapsulation efficiency for doxorubicin, at over 500 µg per mg of carrier. Moreover, the intensity of the initial burst was clearly diminished after coating, hence represents an advantage of using the hybrid system over simple iron oxide nanoparticles. Cytotoxicity studies demonstrate the increase in cytotoxicity of doxorubicin when loaded in nanoparticles, indirectly proving the role played by the carrier and its surface properties in cell uptake. Режим доступа: по договору с организацией-держателем ресурса
Dil:	İngilizce
Baskı/Yayın Bilgisi:	2017
Konular:	труды учёных ТПУ электронный ресурс iron nanoparticles chitosan polylactic acid controlled release doxorubicinchitosan железные наночастицы хитозан полимолочная кислота доксорубицин
Online Erişim:	https://doi.org/10.1016/j.ijpharm.2017.04.061
Materyal Türü:	Elektronik Kitap Bölümü
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=655682