Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders; Neurochemical Journal; Vol. 11, iss. 2

Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders; Neurochemical Journal; Vol. 11, iss. 2

Bibliografske podrobnosti
Parent link:Neurochemical Journal
Vol. 11, iss. 2.— 2017.— [P. 185–187]
Korporativna značnica: Национальный исследовательский Томский политехнический университет (ТПУ) Институт неразрушающего контроля (ИНК) Кафедра экологии и безопасности жизнедеятельности (ЭБЖ)
Drugi avtorji: Levchuk L. A. Lyudmila Aleksandrovna, Vyalova N. M. Nataljya Mikhaylovna, Simutkin G. G. German Gennadjevich, Bokhan N. A. Nikolay Aleksandrovich, Ivanova S. A. Svetlana Aleksandrovna
Izvleček:Title screen
We present a comprehensive clinical and biological study of 46 patients with depressive disorder (F32-F33: depressive episode and recurrent depressive disorder) during pharmacotherapy. Neurohumoral factors (cortisol, brain-derived neurotrophic factor, serotonin, DHEA and its sulfated form) were determined in serum by ELISA. The severity of the current depressive episode was evaluated using the 17-point Hamilton Depression Rating Scale (HDRS-17); the pharmacotherapy efficacy was evaluated using the scale of the Clinical Global Impression (CGI Scale). We showed that before prescription of pharmacotherapy peripheral blood neurohumoral markers that characterize the state of stress-realizing and stress-limiting systems of the body may be considered as biological predictors of the effective pharmacotherapy of a current depressive episode and used as additional paraclinical examination methods. At higher concentrations of cortisol and serotonin associated with a decrease in the content of neurosteroid dehydroepiandrosterone, the high efficiency of the pharmacotherapy of depressive episode is predicted.
Режим доступа: по договору с организацией-держателем ресурса
Jezik:angleščina
Izdano: 2017
Teme:
электронный ресурс
труды учёных ТПУ
depressive disorder
pharmacotherapy
neurohumoral system
депрессивные расстройства
нейрогуморальные системы
фармакотерапия
Online dostop:https://doi.org/10.1134/S1819712417020088
Format: Elektronski Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=655541

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