Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders

Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders

Dades bibliogràfiques
Parent link:Neurochemical Journal
Vol. 11, iss. 2.— 2017.— [P. 185–187]
Autor corporatiu: Национальный исследовательский Томский политехнический университет (ТПУ) Институт неразрушающего контроля (ИНК) Кафедра экологии и безопасности жизнедеятельности (ЭБЖ)
Altres autors: Levchuk L. A. Lyudmila Aleksandrovna, Vyalova N. M. Nataljya Mikhaylovna, Simutkin G. G. German Gennadjevich, Bokhan N. A. Nikolay Aleksandrovich, Ivanova S. A. Svetlana Aleksandrovna
Sumari:Title screen
We present a comprehensive clinical and biological study of 46 patients with depressive disorder (F32-F33: depressive episode and recurrent depressive disorder) during pharmacotherapy. Neurohumoral factors (cortisol, brain-derived neurotrophic factor, serotonin, DHEA and its sulfated form) were determined in serum by ELISA. The severity of the current depressive episode was evaluated using the 17-point Hamilton Depression Rating Scale (HDRS-17); the pharmacotherapy efficacy was evaluated using the scale of the Clinical Global Impression (CGI Scale). We showed that before prescription of pharmacotherapy peripheral blood neurohumoral markers that characterize the state of stress-realizing and stress-limiting systems of the body may be considered as biological predictors of the effective pharmacotherapy of a current depressive episode and used as additional paraclinical examination methods. At higher concentrations of cortisol and serotonin associated with a decrease in the content of neurosteroid dehydroepiandrosterone, the high efficiency of the pharmacotherapy of depressive episode is predicted.
Режим доступа: по договору с организацией-держателем ресурса
Publicat: 2017
Matèries:
электронный ресурс
труды учёных ТПУ
depressive disorder
pharmacotherapy
neurohumoral system
депрессивные расстройства
нейрогуморальные системы
фармакотерапия
Accés en línia:https://doi.org/10.1134/S1819712417020088
Format: Electrònic Capítol de llibre
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=655541

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