New Cytochrome P-450 Ligands Based on Urea Derivatives; Pharmaceutical Chemistry Journal; Vol. 39, iss. 1

New Cytochrome P-450 Ligands Based on Urea Derivatives; Pharmaceutical Chemistry Journal; Vol. 39, iss. 1

Detaylı Bibliyografya
Parent link:	Pharmaceutical Chemistry Journal Vol. 39, iss. 1.— 2005.— [P. 18-21]
Diğer Yazarlar:	Khlebnikov A. I. Andrey Ivanovich, Achmedshanow R. R. Rafik Rawiliewich, Naboka O. I., Bakibaev A. A. Abdigali Abdimanapovich, Tartynova M. I., Novozheeva T. P., Saratikov А. S.
Özet:	Title screen Cytochrome P-450 (CYPIIB1 isoform) ligands were constructed de novo on the basis of QSAR models derived using the frontal polygon (FP) method. The following compounds were designed and synthesized: 2-phenyl-6-benzyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione, N-acetyl-N?-(1-phenylethyl)urea, and (1-phenyl-3-methylbutyl)urea. Their interaction with phenobarbital-induced microsomes isolated from rat liver was studied spectrophotometrically. The dissociation constants Ks of the enzyme - substrate complexes measured are in good agreement with the values predicted using the QSAR models. The results show that the FP method has a high potential for designing biologically active compounds. Режим доступа: по договору с организацией-держателем ресурса
Dil:	İngilizce
Baskı/Yayın Bilgisi:	2005
Konular:	электронный ресурс труды учёных ТПУ мочевина модели микросомы печень биологически активные соединения цитохрома Р-450 лиганды моделирование
Online Erişim:	http://dx.doi.org/10.1007/s11094-005-0071-6
Materyal Türü:	Elektronik Kitap Bölümü
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=654378

Benzer Materyaller

Конструирование новых лигандов цитохрома Р-450 среди соединений мочевины; Химико-фармацевтический журнал; Т. 39, № 1
Baskı/Yayın Bilgisi: (2005)

Влияние некоторых азотсодержащих соединений - лигандов цитохрома P-450 на монооксигеназную систему печени крыс; Технология органических веществ и высокомолекулярных соединений
Baskı/Yayın Bilgisi: (2003)

Регуляторы ферментативных систем детоксикации среди азотсодержащих соединений
Baskı/Yayın Bilgisi: (Томск, Сибирский издательский дом, 2002)

Amide- and urea-based synthetic anticonvulsants, antihypoxics, and inducers of the hepatic monooxygenase system; VII; Effect of benzhydrylureas on the cytochrome P-450-dependent liver monooxygenase system; Pharmaceutical Chemistry Journal; Vol. 27, iss. 6
Baskı/Yayın Bilgisi: (1993)

Amide- and urea-based synthetic anticonvulsants, antihypoxics, and inducers of the hepatic monooxygenase system; IX; Synthesis and search for inducers of the liver cytochrome P-450-dependent monooxygenase system among carbamide-containing heterocyclic compounds; Pharmaceutical Chemistry Journal; Vol. 27, iss. 6
Baskı/Yayın Bilgisi: (1993)

Synthetic anticonvulsants, antihypoxics, and liver monooxygenase system inducers based on amides and urea; IV; Antihypoxic activity of benzhydrylurea and its haloid derivatives; Pharmaceutical Chemistry Journal; Vol. 27, iss. 4
Baskı/Yayın Bilgisi: (1993)

Application of the frontal polygon method in analysis of the structure - activity relation for urea derivatives: inducers of cytochrome p-450 in the liver; Pharmaceutical Chemistry Journal; Vol. 29, iss. 7
Baskı/Yayın Bilgisi: (1995)

Synthetic anticonvulsants, antihypoxics, and inducers of the liver monooxygenase system based on amides and ureas; XVI; Studies of the antihypoxic properties of bicyclic bis-ureas; Pharmaceutical Chemistry Journal; Vol. 28, iss. 8
Baskı/Yayın Bilgisi: (1994)

Synthetic anticonvulsants, antihypoxics, and inducers of the liver monooxygenase system based on amides and ureas; XVII; Synthesis of N-benzhydryl-N′-(heteroyl)ureas and studies of their anticonvulsive activity; Pharmaceutical Chemistry Journal; Vol. 28, iss. 8
Baskı/Yayın Bilgisi: (1994)

Synthetic anticonvulsants, antihypoxic agents, and liver monooxygenase inducers based on amides and urea; 3; Synthesis and anticonvulsive and antihypoxic activities of cyclohexylalkoxynaphthylmethylureas; Pharmaceutical Chemistry Journal; Vol. 27, iss. 3
Baskı/Yayın Bilgisi: (1993)

Synthetic anticonvulsants, antihypoxics, and liver monooxygenase system inducers based on amides and urea; V; Synthesis and anticonvulsive and antihypoxic activities of 1,3 dibenzhydrylureas; Pharmaceutical Chemistry Journal; Vol. 27, iss. 4
Baskı/Yayın Bilgisi: (1993)

Amide- and urea-based synthetic anticonvulsants, antihypoxics, and inducers of the hepatic monooxygenase system; VIII; Effect of benzhydrylureas and m-chlorobenzhydrylureas on the rat liver monooxygenase system; Pharmaceutical Chemistry Journal; Vol. 27, iss. 6
Baskı/Yayın Bilgisi: (1993)

Synthetic anticonvulsants, antihypoxics, and liver monooxygenase system inducers based on amides and urea; VI; Synthesis and search for liver monooxygenase system inducers among compounds containing the benzhydryl group; Pharmaceutical Chemistry Journal; Vol. 27, iss. 4
Baskı/Yayın Bilgisi: (1993)

Synthetic anticonvulsants, antihypoxics, and inducers of the liver monooxygenase system based on amides and urea; XV; Synthesis and biological activity of newortho-substituted benzhydrylureas: Potential synthones of quinazolines and benzodiazepines; Pharmaceutical Chemistry Journal; Vol. 28, iss. 7
Baskı/Yayın Bilgisi: (1994)

Молекулярное моделирование биологически активных соединений лигандов для ГАМКА рецепторов; Перспективы развития фундаментальных наук; Т. 4 : Биология и фундаментальная медицина
Yazar:: Иманкулова Е. А.
Baskı/Yayın Bilgisi: (2018)

Synthetic anticonvulsants, antihypoxic agents, and inducers of the liver monooxygenase system; XII; The enzyme-inducing activity of N-aralkyl-N-acylureas; Pharmaceutical Chemistry Journal; Vol. 28, iss. 3
Baskı/Yayın Bilgisi: (1994)

Активация кислорода ферментными системами
Yazar:: Метелица Д. И. Дмитрий Иванович
Baskı/Yayın Bilgisi: (Москва, Наука, 1982)

Synthesis of phosphorylated urea derivatives; Theoretical and experimental chemistry
Yazar:: Gorbin S. I.
Baskı/Yayın Bilgisi: (2017)

Cytochrome P450 Protocols
Baskı/Yayın Bilgisi: (2013)

Cytochrome P450 Protocols
Baskı/Yayın Bilgisi: (1998)

Cytochrome P450 Protocols
Baskı/Yayın Bilgisi: (2006)

Cytochrome P450 In Vitro Methods and Protocols /
Baskı/Yayın Bilgisi: (2021)

Application of Sulfated Magnetic Nanoparticles in the Synthesis of Biologically Active Ureas; Applied Mechanics and Materials; Vol. 1097 : Nanomaterials and Surface Technologies, Materials Applications
Baskı/Yayın Bilgisi: (2015)

Synthetic anticonvulsants, antehypoxants, and inducers of the hepatic monooxygenase system based on amides and ureas; II; Synthesis, anticonvulsant, antihypoxic, and enzyme-inducing properties of N-trifluoroacetyl derivatives of benzhydrylamines; Pharmaceutical Chemistry Journal; Vol. 26, iss. 11
Baskı/Yayın Bilgisi: (1993)

Quantitative structure - Activity relationships in a series of urea derivatives - Liver cytochrome P-450 inductors analyzed by the modified method of frontal polyhedral; Pharmaceutical Chemistry Journal; Vol. 31, iss. 6
Baskı/Yayın Bilgisi: (1997)

Treatment of Alcoholic Patients Using Anticonvulsant Urea Derivative Influences the Metabolism of Neuro-active Steroid Hormones - The System of Stress Markers; Journal of Addiction Research & Therapy; Vol. 7, iss. 2
Baskı/Yayın Bilgisi: (2016)

Synthesis of 3-Phenylisoindolinones by Reaction of 2-Carboxybenzophenone and 2-Methoxycarbonylbenzophenone with Ureas in Formic Acid; Russian Journal of Organic Chemistry; Vol. 39, iss. 8
Yazar:: Bakibaev A. A. Abdigali Abdimanapovich
Baskı/Yayın Bilgisi: (2003)

Original Anticonvulsant Urea Derivative Alters the Properties of Benzodiazepine Receptors Central and Peripheral Types in the Cerebral Cortex of Heavy Drinkers Rats; Journal of Alcoholism & Drug Dependence; Vol. 4, iss. 2
Baskı/Yayın Bilgisi: (2016)

Новые реакции бетулина с производными мочевины; Химия и химическая технология в XXI веке
Yazar:: Прасолов П. В.
Baskı/Yayın Bilgisi: (2018)

Прямое вольтамперометрическое определение галодифа; Химия и химическая технология в XXI веке
Yazar:: Репкин Д. С.
Baskı/Yayın Bilgisi: (2019)

Микросомальное окисление
Yazar:: Арчаков А. И. Александр Иванович
Baskı/Yayın Bilgisi: (Москва, Наука, 1975)

Основы фармакогенетики учебное пособие
Yazar:: Мустафин Р. Н.
Baskı/Yayın Bilgisi: (Уфа, БГМУ, 2020)

Part II: Inorganic Ligands; Stability Constants of Metal-ion Complexes, with Solubility Products of Inorganic Substances
Baskı/Yayın Bilgisi: (1958)

Экспериментальное и теоретическое исследование механизма реакции бензила с мочевинами в синтезах биологически активных соединений; Химия и химическая технология в XXI веке; Т. 1
Yazar:: Ховренко Е. В. Елена Владиславовна
Baskı/Yayın Bilgisi: (2022)

Metal-Ligand Interactions. Molecular, Nano- Micro- and Macro-systems in Complex Environments
Baskı/Yayın Bilgisi: (Dordrecht, Kluwer Academic Publishers, 2003)

Синтез жёстких лигандов на основе имидазола; Химия и химическая технология в XXI веке
Yazar:: Марченко Р. Д. Роман Дмитриевич
Baskı/Yayın Bilgisi: (2019)

Mechanochemical Preparation of Slow Release Fertilizer Based on Glauconite–Urea Complexes; Minerals; Vol. 9, iss. 9
Baskı/Yayın Bilgisi: (2019)

Методы синтеза азотсодержащих циклических соединений на основе глиоксаля и его производных реакцией переиминирования: диссертация на соискание ученой степени кандидата химических наук; спец. 02.00.03
Yazar:: Чикина М. В. Майя Викторовна
Baskı/Yayın Bilgisi: (Бийск, [Б. и.], 2016)

Методы синтеза азотсодержащих циклических соединений на основе глиоксаля и его производных реакцией переиминирования: автореферат диссертации на соискание ученой степени кандидата химических наук; спец. 02.00.03
Yazar:: Чикина М. В. Майя Викторовна
Baskı/Yayın Bilgisi: (Томск, [Б. и.], 2016)

New synthesis of iminodiacetate ligands; Химия и химическая технология в XXI веке
Yazar:: Noskov D. M. Dmitry Mikhaylovich
Baskı/Yayın Bilgisi: (2019)