Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia; The World Journal of Biological Psychiatry; Vol. 18, iss. 3

Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia; The World Journal of Biological Psychiatry; Vol. 18, iss. 3

Bibliographic Details
Parent link:The World Journal of Biological Psychiatry
Vol. 18, iss. 3.— 2016.— [P. 239-246]
Corporate Author: Национальный исследовательский Томский политехнический университет (ТПУ) Институт неразрушающего контроля (ИНК) Кафедра экологии и безопасности жизнедеятельности (ЭБЖ)
Other Authors: Ivanova S. A. Svetlana Aleksandrovna, Osmanova D. Z. Diana, Freydin M. V., Fedorenko O. Yu. Olga Yurievna, Boyko A. S. Anastasiya Sergeevna, Pozhidaev I. V. Ivan, Semke A. V. Arkady Valentinovich, Bokhan N. A. Nikolay Aleksandrovich, Agarkov A. A. Aleksey Aleksandrovich, Vilffert B. Bob, Loonen A. J. M. Anton
Summary:Title screen
Objectives: Hyperprolactinaemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 subtype receptors in the pituitary gland. Although dopamine is considered the primary factor inhibiting prolactin release, the activity of prolactin-producing lactotrophs is also regulated by the secretagogues thyrotrophin releasing hormone, vasoactive intestinal polypeptide and serotonin (5-hydroxytryptamine; 5-HT). Methods: We describe the association between HPRL and a set of 29 SNPs from 5-HT receptor genes HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B and HTR6 in a population of 446 Caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to ICD-10: F20) who were treated with classical and/or atypical antipsychotic drugs. Results: None of the studied autosomal markers were found to be associated with HPRL. However, a significant association was established between various HTR2C polymorphisms and HPRL. Conclusions: This study revealed an association between HPRL and X-chromosome haplotypes comprised of the rs569959 and rs17326429 polymorphisms.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2016
Subjects:
электронный ресурс
труды учёных ТПУ
polymorphism
antipsychotics
schizophrenia
полиморфизм
шизофрения
Online Access:http://dx.doi.org/10.1080/15622975.2016.1224926
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=654150

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