Exposure of nano- and ultrafine Ni particles to synthetic biological solutions: predicting fate-related dissolution and accumulation; European Journal of Nanomedicine; Vol. 8, iss. 4

Exposure of nano- and ultrafine Ni particles to synthetic biological solutions: predicting fate-related dissolution and accumulation; European Journal of Nanomedicine; Vol. 8, iss. 4

Podrobná bibliografie
Parent link:	European Journal of Nanomedicine Vol. 8, iss. 4.— 2016.— [P. 203-212]
Korporativní autor:	Национальный исследовательский Томский политехнический университет
Další autoři:	Abzhanova D. B. Diana Beybitovna, Godymchuk (Godimchuk) A. Yu. Anna Yuryevna, Gusev A. A. Aleksandr Anatoljevich, Kuznetsov D. V. Denis Valerjevich
Shrnutí:	Title screen The growing production and use of nickel (Ni) nanopowders with low biopersistence makes dissolution and accumulation degree in a body an important parameters needed for the risk assessment of nanoparticles. We propose an experimental approach for rapid determination of the dissolution degree of nanoscale (77 nm) and ultrafine (275 nm) Ni particles in synthetic biological solutions. It has been shown that after 2 h of exposure to simulating saliva and lysosomal liquid the dissolution degree of nanoparticles can reach 30 and 60 wt.%, respectively. With decreasing of the particle's size, they are characterized by increased solubility in saliva and the pulmonary tract; and the particles completely dissolve in 24 h. There was an attempt to predict the potential extent of accumulation of nickel compounds in the human body with particles entering the body by saliva or with breathing: with 3.8 times size decrease the probability of nickel accumulation in a body can rise in 3.5 times.
Jazyk:	angličtina
Vydáno:	2016
Témata:	электронный ресурс труды учёных ТПУ accumulators dissolution накопления растворение наночастицы никель
On-line přístup:	http://dx.doi.org/10.1515/ejnm-2016-0021
Médium:	Elektronický zdroj Kapitola
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=653952

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