Exposure of nano- and ultrafine Ni particles to synthetic biological solutions: predicting fate-related dissolution and accumulation

Exposure of nano- and ultrafine Ni particles to synthetic biological solutions: predicting fate-related dissolution and accumulation

التفاصيل البيبلوغرافية
Parent link:European Journal of Nanomedicine
Vol. 8, iss. 4.— 2016.— [P. 203-212]
مؤلف مشترك: Национальный исследовательский Томский политехнический университет
مؤلفون آخرون: Abzhanova D. B. Diana Beybitovna, Godymchuk (Godimchuk) A. Yu. Anna Yuryevna, Gusev A. A. Aleksandr Anatoljevich, Kuznetsov D. V. Denis Valerjevich
الملخص:Title screen
The growing production and use of nickel (Ni) nanopowders with low biopersistence makes dissolution and accumulation degree in a body an important parameters needed for the risk assessment of nanoparticles. We propose an experimental approach for rapid determination of the dissolution degree of nanoscale (77 nm) and ultrafine (275 nm) Ni particles in synthetic biological solutions. It has been shown that after 2 h of exposure to simulating saliva and lysosomal liquid the dissolution degree of nanoparticles can reach 30 and 60 wt.%, respectively. With decreasing of the particle's size, they are characterized by increased solubility in saliva and the pulmonary tract; and the particles completely dissolve in 24 h. There was an attempt to predict the potential extent of accumulation of nickel compounds in the human body with particles entering the body by saliva or with breathing: with 3.8 times size decrease the probability of nickel accumulation in a body can rise in 3.5 times.
اللغة:الإنجليزية
منشور في: 2016
الموضوعات:
электронный ресурс
труды учёных ТПУ
accumulators
dissolution
накопления
растворение
наночастицы
никель
الوصول للمادة أونلاين:http://dx.doi.org/10.1515/ejnm-2016-0021
التنسيق: الكتروني فصل الكتاب
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=653952

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