The use of magnetron sputtering for the deposition of thin titanium coatings on the surface of bioresorbable electrospun fibrous scaffolds for vascular tissue engineering: A pilot study; Applied Surface Science; Vol. 398

The use of magnetron sputtering for the deposition of thin titanium coatings on the surface of bioresorbable electrospun fibrous scaffolds for vascular tissue engineering: A pilot study; Applied Surface Science; Vol. 398

Bibliographic Details
Parent link:Applied Surface Science.— , 1985-
Vol. 398.— 2017.— [P. 63-72]
Corporate Author: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Кафедра экспериментальной физики (ЭФ)
Other Authors: Bolbasov E. N. Evgeny Nikolaevich, Antonova L. V. Larisa Valerjevna, Stankevich K. S. Ksenia Sergeevna, Ashrafov A. Kh. Andrey Khakimovich, Matveeva V. G. Vera Gennadjevna, Velikanova E. A. Elena Anatoljevna, Khodyrevskaya Yu. I. Yuliya Ivanovna, Kudryavtseva Yu. A. Yuliya Aleksandrovna, Anisimov Yu. G. Yury German, Tverdokhlebov S. I. Sergei Ivanovich, Barbarash L. S. Leonid Semenovich
Summary:Title screen
The deposition of thin titanium coatings using magnetron spattering on the surface of bioresorbable fibrous scaffolds produced by electrospinning was investigated. Parameters that allow the surface modification without damaging the “macro” structure of scaffolds were determined. Physicochemical properties of the modified scaffolds were described using SEM, EDS, DSC, optical goniometry, and mechanical testing. It was shown that plasma treatment has a significant influence on the scaffolds’ fiber surface relief. The modification process leads to a slight decrease of the scaffold mechanical performance mainly caused by polymer crystallization. Increasing the deposition time increases the amount of titanium on the surface. The biocompatibility of the modified scaffolds was studied using hybridoma of the endothelial cells of human umbilical vein and human lung carcinoma (EA.hy 926 cell line). Cell adhesion, viability, and secretion of interleukin-6 (IL6), interleukin-8 (IL8), and vascular endothelial growth factor (VEGF) were investigated. It was demonstrated that the deposition of thin titanium coatings on the fibrous scaffolds’ surface enhances cell adhesion. Additionally, it was determined that modified scaffolds have proangiogenic activity.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2017
Subjects:
электронный ресурс
труды учёных ТПУ
поли-е -капролактон
титан
тонкие пленки
магнетронное распыление
биосовместимость
Online Access:http://dx.doi.org/10.1016/j.apsusc.2016.12.033
Format: MixedMaterials Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652892

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