Triple-responsive inorganic–organic hybrid microcapsules as a biocompatible smart platform for the delivery of small molecules; Journal of Materials Chemistry B; Vol. 4, iss. 45

গ্রন্থ-পঞ্জীর বিবরন
Parent link:	Journal of Materials Chemistry B.— , 2013- Vol. 4, iss. 45.— 2016.— [P. 7270-7282]
সংস্থা লেখক:	Национальный исследовательский Томский политехнический университет (ТПУ) Управление проректора по научной работе и инновациям (НРиИ) Центр RASA в Томске Лаборатория новых лекарственных форм (Лаб. НЛФ)
অন্যান্য লেখক:	Timin A. S. Aleksandr Sergeevich, Muslimov A. R. Albert, Lepik K. L. Kirill, Saprykina N. N. Natalia, Sergeev S. S. Vladislav, Afanasyev B. V. Boris, Vilesov A. D. Alexander, Sukhorukov G. B. Gleb Borisovich
সংক্ষিপ্ত:	Title screen We designed novel hybrid inorganic/organic capsules with unique physicochemical features enabling multimodal triggering by physical (UV light, ultrasound) and chemical (enzymatic treatment) stimuli. Notably, the UV- and ultrasound response was achieved by a synergetic combination of TiO2 and SiO2 nanostructures which were in situ deposited into the polymer shell of microcapsules during sol–gel synthesis. This results in the formation of a composite hybrid shell with enhanced mechanical stability. Such sol–gel modification reduces the permeability of the capsule shell to allow for small molecule encapsulation. At the same time, these hybrid capsules consist of degradable polypeptides and polysaccharides and can be decomposed in response to enzymatic reaction. Upon employing different modes of treatment (UV-light, ultrasound or enzymatic degradation) we can stimulate different mechanisms of cargo release at desired times. Importantly, such capsules have been shown to be non-cytotoxic and can be internalized into human mesenchymal stem cells (MSCs) and cervical cancer cell lines (HeLa) revealing intracellular degradation. This work demonstrates that our hybrid capsules possess a triple stimuli-responsive effect, which is of capital importance for the future design and application of multimodal responsive platforms to improve externally stimulated release of bioactive compounds and their healthcare performance. Режим доступа: по договору с организацией-держателем ресурса
ভাষা:	ইংরেজি
প্রকাশিত:	2016
বিষয়গুলি:	электронный ресурс труды учёных ТПУ микрокапсулы молекулы биосовместимость
অনলাইন ব্যবহার করুন:	http://dx.doi.org/10.1039/C6TB02289H
বিন্যাস:	বৈদ্যুতিক গ্রন্থের অধ্যায়
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652679