Mesenchymal Stem Cell Magnetization: Magnetic Multilayer Microcapsule Uptake, Toxicity, Impact on Functional Properties, and Perspectives for Magnetic Delivery

Mesenchymal Stem Cell Magnetization: Magnetic Multilayer Microcapsule Uptake, Toxicity, Impact on Functional Properties, and Perspectives for Magnetic Delivery

Dettagli Bibliografici
Parent link:Advanced Healthcare Materials
Vol. 5, iss. 24.— 2016.— [P. 3182–3190]
Ente Autore: Национальный исследовательский Томский политехнический университет (ТПУ) Институт природных ресурсов (ИПР) Кафедра технологии органических веществ и полимерных материалов (ТОВПМ)
Altri autori: Lepik K. V. Kirill, Muslimov A. R. Albert, Timin A. S. Aleksandr Sergeevich, Sergeev V. S. Vladislav, Romanyuk D. S. Dmitry, Moiseev I. S. Ivan, Popova E. V. Elena, Radchenko I. L. Igor, Vilesov A. D. Alexander, Galibin O. V. Oleg, Sukhorukov G. B. Gleb, Afanasyev B. V. Boris
Riassunto:Title screen
Mesenchymal stem cells (MSCs) are widely used in cell therapy due to their convenience, multiline differentiation potential, reproducible protocols, and biological properties. The potential of MSCs to impregnate magnetic microcapsules and their possible influence on cell function and ability to response to magnetic field have been explored. Interestingly, the cells suspended in media show much higher ability in internalization of microcapsules, then MSCs adhere into the surface. There is no significant effect of microcapsules on cell toxicity compared with other cell line-capsule internalization reported in literature. Due to internalization of magnetic capsules by the cells, such cell engineering platform is responsive to external magnetic field, which allows to manipulate MSC migration. Magnetically sorted MSCs are capable to differentiation as confirmed by their conversion to adipogenic and osteogenic cells using standard protocols. There is a minor effect of capsule internalization on cell adhesion, though MSCs are still able to form spheroid made by dozen of thousand MSCs. This work demonstrates the potential of use of microcapsule impregnated MSCs to carry internalized micron-sized vesicles and being navigated with external magnetic signaling.
Режим доступа: по договору с организацией-держателем ресурса
Pubblicazione: 2016
Soggetti:
электронный ресурс
труды учёных ТПУ
стволовые клетки
мультипотентные мезенхимальные стромальные клетки
клеточная терапия
Accesso online:http://dx.doi.org/10.1002/adhm.201600843
Natura: Elettronico Capitolo di libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652456

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