Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

Bibliographic Details
Parent link:Medicinal Research Reviews
Vol. 36, iss. 5.— 2016.— [P. 871-923]
Corporate Author: Национальный исследовательский Томский политехнический университет Физико-технический институт Лаборатория № 31 ядерного реактора
Other Authors: Maslov L. N. Leonid Nikolaevich, Khaliulin I. G. Igor Germanovich, Oeltgen P. R. Peter, Naryzhnaya N. V. Nataliya Vladimirovna, Pei Jian-Ming, Brown Stephen, Lishmanov Yu. B. Yury Borisovich, Downey J. M. James
Summary:Title screen
It has now been demonstrated that the µ, δ 1, δ 2, and K 1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct-reducing effect with prophylactic administration and prevent reperfusion-induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia-induced arrhythmias.
Режим доступа: по договору с организацией-держателем ресурса
Published: 2016
Subjects:
электронный ресурс
труды учёных ТПУ
opioids
опиоиды
ишемия
реперфузия
Online Access:http://dx.doi.org/10.1002/med.21395
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652384

Similar Items

Similar Items