Magnetic polymer-silica composites as bioluminescent sensors for bilirubin detection; Materials Chemistry and Physics; Vol. 183

Magnetic polymer-silica composites as bioluminescent sensors for bilirubin detection

Detalles Bibliográficos
Parent link:Materials Chemistry and Physics
Vol. 183.— 2016.— [P. 422-429]
Autor Corporativo: Национальный исследовательский Томский политехнический университет Управление проректора по научной работе и инновациям Центр RASA в Томске Лаборатория новых лекарственных форм
Outros autores: Timin A. S. Aleksandr Sergeevich, Solomonov A. V. Alexey, Kumagai A. Akiko, Miyawaki A. Atsushi, Khashirova S. Yu. Svetlana, Zhansitov A. Azamat, Rumyantsev E. V. Evgeniy
Summary:Title screen
The synthesis of multifunctional nano-sized materials is leading to the rapid development of key application, including improved drug delivery, bioimaging and protein separation. In this work, magnetic silica particles modified with novel guanidine containing co-polymers were manufactured via sol-gel method. To evaluate the chemical composition of our prepared samples, FT-IR spectroscopy and thermogravimetry were conducted. Scanning electron microscopy was used in order to investigate the morphology of final products after modification by guanidine containing co-polymers and iron nanoparticles. In addition, the surface of polymer-silica composites was functionalized by the novel bilirubin-inducible fluorescent protein UnaG. In an aqueous bilirubin solution, the silica particles decorated with the polymer-UnaG have showed bright fluorescence. Synthesis and characterization of these hybrid materials allow developing of new multifunctional nano-sized materials, which will be used for detection and separation of bilirubin, a lipophilic heme catabolite that is a clinical diagnostic for liver function.
Режим доступа: по договору с организацией-держателем ресурса
Idioma:inglés
Publicado: 2016
Subjects:
электронный ресурс
труды учёных ТПУ
полимеры
кремний
композиты
биолюминесцентный мониторинг
Acceso en liña:http://dx.doi.org/10.1016/j.matchemphys.2016.08.048
Formato: Electrónico Capítulo de libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652368

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