Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents

Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents

Bibliographic Details
Parent link:Journal of Agricultural and Food Chemistry.— , 1953-
Vol. 64, № 38.— 2016.— [P. 7156–7170]
Corporate Author: Национальный исследовательский Томский политехнический университет Институт физики высоких технологий Кафедра биотехнологии и органической химии
Other Authors: Schepetkin (Shchepyotkin) I. A. Igor Aleksandrovich, Kushnarenko S. V. Svetlana, Ozek G. Gulmira, Kirpotina L. N. Liliya Nikolaevna, Sinharoy P. Pritam, Utegenova G. A. Gulzhakhan, Abidkulova K. T. Karime, Ozek T. Temel, Baser K. H. C. Kemal Husnu Can, Kovrizhina A. R. Anastasia Ruslanovna, Khlebnikov A. I. Andrey Ivanovich, Damron D. S. Derek, Quinn M. T. Mark
Summary:Title screen
Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gas chromatography-mass spectrometry. Fifty-two compounds were identified in FAEOu/s; the primary components were sabinene, α-pinene, β-pinene, terpinen-4-ol, eremophilene, and 2-himachalen-7-ol, whereas the primary components of FAEOstm were myristicin and geranylacetone. FAEOu/s, β-pinene, sabinene, γ-terpinene, geranylacetone, isobornyl acetate, and (E)-2-nonenal stimulated [Ca2+]i mobilization in human neutrophils, with the most potent being geranylacetone (EC50 = 7.6 ± 1.9 μM) and isobornyl acetate 6.4 ± 1.7 (EC50 = 7.6 ± 1.9 μM). In addition, treatment of neutrophils with β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca2+]i flux and inhibited fMLF-induced chemotaxis. The effects of β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate on neutrophil [Ca2+]i flux were inhibited by transient receptor potential (TRP) channel blockers.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2016
Subjects:
электронный ресурс
труды учёных ТПУ
эфирные масла
человеческий организм
реакции
Online Access:http://dx.doi.org/10.1021/acs.jafc.6b03205
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652325

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