Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents; Journal of Agricultural and Food Chemistry; Vol. 64, № 38

書誌詳細
Parent link:Journal of Agricultural and Food Chemistry.— , 1953-
Vol. 64, № 38.— 2016.— [P. 7156–7170]
団体著者: Национальный исследовательский Томский политехнический университет Институт физики высоких технологий Кафедра биотехнологии и органической химии
その他の著者: Schepetkin (Shchepyotkin) I. A. Igor Aleksandrovich, Kushnarenko S. V. Svetlana, Ozek G. Gulmira, Kirpotina L. N. Liliya Nikolaevna, Sinharoy P. Pritam, Utegenova G. A. Gulzhakhan, Abidkulova K. T. Karime, Ozek T. Temel, Baser K. H. C. Kemal Husnu Can, Kovrizhina A. R. Anastasia Ruslanovna, Khlebnikov A. I. Andrey Ivanovich, Damron D. S. Derek, Quinn M. T. Mark
要約:Title screen
Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gas chromatography-mass spectrometry. Fifty-two compounds were identified in FAEOu/s; the primary components were sabinene, α-pinene, β-pinene, terpinen-4-ol, eremophilene, and 2-himachalen-7-ol, whereas the primary components of FAEOstm were myristicin and geranylacetone. FAEOu/s, β-pinene, sabinene, γ-terpinene, geranylacetone, isobornyl acetate, and (E)-2-nonenal stimulated [Ca2+]i mobilization in human neutrophils, with the most potent being geranylacetone (EC50 = 7.6 ± 1.9 μM) and isobornyl acetate 6.4 ± 1.7 (EC50 = 7.6 ± 1.9 μM). In addition, treatment of neutrophils with β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca2+]i flux and inhibited fMLF-induced chemotaxis. The effects of β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate on neutrophil [Ca2+]i flux were inhibited by transient receptor potential (TRP) channel blockers.
Режим доступа: по договору с организацией-держателем ресурса
言語:英語
出版事項: 2016
主題:
オンライン・アクセス:http://dx.doi.org/10.1021/acs.jafc.6b03205
フォーマット: 電子媒体 図書の章
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652325

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