Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents; Journal of Agricultural and Food Chemistry; Vol. 64, № 38

Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents; Journal of Agricultural and Food Chemistry; Vol. 64, № 38

Podrobná bibliografie
Parent link:Journal of Agricultural and Food Chemistry.— , 1953-
Vol. 64, № 38.— 2016.— [P. 7156–7170]
Korporativní autor: Национальный исследовательский Томский политехнический университет Институт физики высоких технологий Кафедра биотехнологии и органической химии
Další autoři: Schepetkin (Shchepyotkin) I. A. Igor Aleksandrovich, Kushnarenko S. V. Svetlana, Ozek G. Gulmira, Kirpotina L. N. Liliya Nikolaevna, Sinharoy P. Pritam, Utegenova G. A. Gulzhakhan, Abidkulova K. T. Karime, Ozek T. Temel, Baser K. H. C. Kemal Husnu Can, Kovrizhina A. R. Anastasia Ruslanovna, Khlebnikov A. I. Andrey Ivanovich, Damron D. S. Derek, Quinn M. T. Mark
Shrnutí:Title screen
Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gas chromatography-mass spectrometry. Fifty-two compounds were identified in FAEOu/s; the primary components were sabinene, α-pinene, β-pinene, terpinen-4-ol, eremophilene, and 2-himachalen-7-ol, whereas the primary components of FAEOstm were myristicin and geranylacetone. FAEOu/s, β-pinene, sabinene, γ-terpinene, geranylacetone, isobornyl acetate, and (E)-2-nonenal stimulated [Ca2+]i mobilization in human neutrophils, with the most potent being geranylacetone (EC50 = 7.6 ± 1.9 μM) and isobornyl acetate 6.4 ± 1.7 (EC50 = 7.6 ± 1.9 μM). In addition, treatment of neutrophils with β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca2+]i flux and inhibited fMLF-induced chemotaxis. The effects of β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate on neutrophil [Ca2+]i flux were inhibited by transient receptor potential (TRP) channel blockers.
Режим доступа: по договору с организацией-держателем ресурса
Jazyk:angličtina
Vydáno: 2016
Témata:
электронный ресурс
труды учёных ТПУ
эфирные масла
человеческий организм
реакции
On-line přístup:http://dx.doi.org/10.1021/acs.jafc.6b03205
Médium: Elektronický zdroj Kapitola
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652325

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