Design, synthesis and evaluation of a new Mn – Contrast agent for MR imaging of myocardium based on the DTPA-phenylpentadecanoic acid complex
| Parent link: | Chemical Physics Letters Vol. 665.— 2016.— [P. 111-116] |
|---|---|
| Corporate Authors: | , |
| Other Authors: | , , , , , , |
| Summary: | Title screen In the present paper we describe the first synthesis and evaluation of a novel Mn (II) complex (DTPA-PPDA Mn (II)) which contains a C-15 fatty acid moiety that has high affinity to the heart muscle. The complexation energy of DTPA-PPDA Mn (II) evaluated by quantum chemistry methodology indicates that it essentially exceeds the corresponding value for the known DTPA Mn (II) complex. Molecular docking revealed that the affinity of the designed complex to the heart-type transport protein H-FABP well exceeds that of lauric acid. Phantom experiments in low-field MRI the designed contrast agent provides MR imaging comparable to gadopentetic acid. Режим доступа: по договору с организацией-держателем ресурса |
| Language: | English |
| Published: |
2016
|
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1016/j.cplett.2016.10.058 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652156 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 652156 | ||
| 005 | 20250327103720.0 | ||
| 035 | |a (RuTPU)RU\TPU\network\17419 | ||
| 090 | |a 652156 | ||
| 100 | |a 20161202d2016 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a Design, synthesis and evaluation of a new Mn – Contrast agent for MR imaging of myocardium based on the DTPA-phenylpentadecanoic acid complex |f M. L. Belyanin [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 48 tit.] | ||
| 330 | |a In the present paper we describe the first synthesis and evaluation of a novel Mn (II) complex (DTPA-PPDA Mn (II)) which contains a C-15 fatty acid moiety that has high affinity to the heart muscle. The complexation energy of DTPA-PPDA Mn (II) evaluated by quantum chemistry methodology indicates that it essentially exceeds the corresponding value for the known DTPA Mn (II) complex. Molecular docking revealed that the affinity of the designed complex to the heart-type transport protein H-FABP well exceeds that of lauric acid. Phantom experiments in low-field MRI the designed contrast agent provides MR imaging comparable to gadopentetic acid. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Chemical Physics Letters | ||
| 463 | |t Vol. 665 |v [P. 111-116] |d 2016 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a контрастное обнаружение | |
| 610 | 1 | |a ДПФ | |
| 610 | 1 | |a марганец | |
| 610 | 1 | |a гадолиний | |
| 701 | 1 | |a Belyanin |b M. L. |c organic chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of chemical sciences |f 1973- |g Maksim L'vovich |3 (RuTPU)RU\TPU\pers\31268 |9 15446 | |
| 701 | 1 | |a Stepanova |b E. V. |c chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1988- |g Elena Vladimirovna |3 (RuTPU)RU\TPU\pers\34245 |9 17776 | |
| 701 | 1 | |a Valiev |b R. R. |c chemist |c Assistant of Tomsk Polytechnic University |f 1983- |g Rashid Rinatovich |3 (RuTPU)RU\TPU\pers\34114 | |
| 701 | 1 | |a Filimonov |b V. D. |c Russian chemist |c Professor of the TPU |f 1945- |g Viktor Dmitrievich |3 (RuTPU)RU\TPU\pers\26423 |9 12127 | |
| 701 | 1 | |a Usov |b V. Yu. |g Vladimir Yurjevich | |
| 701 | 1 | |a Borodin |b O. Yu. |g Oleg Yurjevich | |
| 701 | 1 | |a Hans |b A. |g Agren | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет (ТПУ) |b Институт физики высоких технологий (ИФВТ) |b Кафедра биотехнологии и органической химии (БИОХ) |3 (RuTPU)RU\TPU\col\18693 |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Институт физики высоких технологий |b Кафедра общей химии и химической технологии |3 (RuTPU)RU\TPU\col\21253 |9 27944 |
| 801 | 2 | |a RU |b 63413507 |c 20161202 |g RCR | |
| 856 | 4 | |u http://dx.doi.org/10.1016/j.cplett.2016.10.058 | |
| 942 | |c CF | ||