Design, synthesis and evaluation of a new Mn – Contrast agent for MR imaging of myocardium based on the DTPA-phenylpentadecanoic acid complex

Design, synthesis and evaluation of a new Mn – Contrast agent for MR imaging of myocardium based on the DTPA-phenylpentadecanoic acid complex

Détails bibliographiques
Parent link:Chemical Physics Letters
Vol. 665.— 2016.— [P. 111-116]
Collectivités auteurs: Национальный исследовательский Томский политехнический университет (ТПУ) Институт физики высоких технологий (ИФВТ) Кафедра биотехнологии и органической химии (БИОХ), Национальный исследовательский Томский политехнический университет Институт физики высоких технологий Кафедра общей химии и химической технологии
Autres auteurs: Belyanin M. L. Maksim L'vovich, Stepanova E. V. Elena Vladimirovna, Valiev R. R. Rashid Rinatovich, Filimonov V. D. Viktor Dmitrievich, Usov V. Yu. Vladimir Yurjevich, Borodin O. Yu. Oleg Yurjevich, Hans A. Agren
Résumé:Title screen
In the present paper we describe the first synthesis and evaluation of a novel Mn (II) complex (DTPA-PPDA Mn (II)) which contains a C-15 fatty acid moiety that has high affinity to the heart muscle. The complexation energy of DTPA-PPDA Mn (II) evaluated by quantum chemistry methodology indicates that it essentially exceeds the corresponding value for the known DTPA Mn (II) complex. Molecular docking revealed that the affinity of the designed complex to the heart-type transport protein H-FABP well exceeds that of lauric acid. Phantom experiments in low-field MRI the designed contrast agent provides MR imaging comparable to gadopentetic acid.
Режим доступа: по договору с организацией-держателем ресурса
Langue:anglais
Publié: 2016
Sujets:
электронный ресурс
труды учёных ТПУ
контрастное обнаружение
ДПФ
марганец
гадолиний
Accès en ligne:http://dx.doi.org/10.1016/j.cplett.2016.10.058
Format: Électronique Chapitre de livre
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652156
Description
Résumé:Title screen
In the present paper we describe the first synthesis and evaluation of a novel Mn (II) complex (DTPA-PPDA Mn (II)) which contains a C-15 fatty acid moiety that has high affinity to the heart muscle. The complexation energy of DTPA-PPDA Mn (II) evaluated by quantum chemistry methodology indicates that it essentially exceeds the corresponding value for the known DTPA Mn (II) complex. Molecular docking revealed that the affinity of the designed complex to the heart-type transport protein H-FABP well exceeds that of lauric acid. Phantom experiments in low-field MRI the designed contrast agent provides MR imaging comparable to gadopentetic acid.
Режим доступа: по договору с организацией-держателем ресурса
DOI:10.1016/j.cplett.2016.10.058

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