Study of potential utility of new radiopharmaceuticals based on technetium-99m labeled derivative of glucose; AIP Conference Proceedings; Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016
| Parent link: | AIP Conference Proceedings Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016.— 2016.— [020072, 4 p.] |
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| Corporate Author: | |
| Other Authors: | , , , , , , , , |
| Summary: | Title screen Purpose: to study the potential utility of 1-thio-D-glucose labeled with {99m}Tc for cancer imaging in laboratory animals. Materials and method: the study was carried out in cell cultures of normal CHO (Chinese hamster ovary cells CHO) and malignant tissues MCF-7 (human breast adenocarcinoma MCF-7). To evaluate the uptake of {99m}Tc-1-thio-D-glucose in normal and tumor tissue cells, 25 MBq of 1-thio-D-glucose labeled with {99m}Tc was added to the vials with 3 million cells and incubated for 30 min at room temperature. After centrifugation of the vials with cells, the supernatant was removed. The radioactivity in vials with normal and tumor cells was then measured. In addition, the study included 40 mice of C57B1/6j lines with tumor lesion of the right femur. For neoplastic lesions, Lewis lung carcinoma model was used. Following anesthesia, mice were injected intravenously with 25 MBq of {99m}Tc-1-thio-D-glucose. Planar scintigraphy was performed 15 minutes later in a matrix of 512x512 pixels for 5 min. Results: when measuring the radioactivity of normal and malignant cells after incubation with {99m}Tc-1-thio-D-glucose, it was found that the radioactivity of malignant cells was higher than that of normal cells. The mean values of radioactivity levels in normal and malignant cells were 0.3±0.15 MBq and 1.07±0.6 MBq, respectively. All examined animals had increased accumulation of {99m}Tc-1-thio-D-glucose at the tumor site. The accumulation of {99m}Tc-1-thio-D-glucose in the tumor was on average twice as high as compared to the symmetric region. Conclusion: The present study demonstrated that {99m}Tc-1-thio-D-glucose is a prospective radiopharmaceutical for cancer visualization. In addition, high accumulation of {99m}Tc-1-thio-D-glucose in the culture of cancer cells and in tumor tissue of animals demonstrates tumor tropism of the radiopharmaceutical. Режим доступа: по договору с организацией-держателем ресурса |
| Language: | English |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1063/1.4960291 http://earchive.tpu.ru/handle/11683/35797 |
| Format: | MixedMaterials Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652063 |
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| 200 | 1 | |a Study of potential utility of new radiopharmaceuticals based on technetium-99m labeled derivative of glucose |f R. V. Zelchan [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 6 tit.] | ||
| 330 | |a Purpose: to study the potential utility of 1-thio-D-glucose labeled with {99m}Tc for cancer imaging in laboratory animals. Materials and method: the study was carried out in cell cultures of normal CHO (Chinese hamster ovary cells CHO) and malignant tissues MCF-7 (human breast adenocarcinoma MCF-7). To evaluate the uptake of {99m}Tc-1-thio-D-glucose in normal and tumor tissue cells, 25 MBq of 1-thio-D-glucose labeled with {99m}Tc was added to the vials with 3 million cells and incubated for 30 min at room temperature. After centrifugation of the vials with cells, the supernatant was removed. The radioactivity in vials with normal and tumor cells was then measured. In addition, the study included 40 mice of C57B1/6j lines with tumor lesion of the right femur. For neoplastic lesions, Lewis lung carcinoma model was used. Following anesthesia, mice were injected intravenously with 25 MBq of {99m}Tc-1-thio-D-glucose. Planar scintigraphy was performed 15 minutes later in a matrix of 512x512 pixels for 5 min. Results: when measuring the radioactivity of normal and malignant cells after incubation with {99m}Tc-1-thio-D-glucose, it was found that the radioactivity of malignant cells was higher than that of normal cells. The mean values of radioactivity levels in normal and malignant cells were 0.3±0.15 MBq and 1.07±0.6 MBq, respectively. All examined animals had increased accumulation of {99m}Tc-1-thio-D-glucose at the tumor site. The accumulation of {99m}Tc-1-thio-D-glucose in the tumor was on average twice as high as compared to the symmetric region. Conclusion: The present study demonstrated that {99m}Tc-1-thio-D-glucose is a prospective radiopharmaceutical for cancer visualization. In addition, high accumulation of {99m}Tc-1-thio-D-glucose in the culture of cancer cells and in tumor tissue of animals demonstrates tumor tropism of the radiopharmaceutical. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | 0 | |0 (RuTPU)RU\TPU\network\4816 |t AIP Conference Proceedings | |
| 463 | 0 | |0 (RuTPU)RU\TPU\network\17033 |t Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016 |o Proceedings of the International conference, 22-25 March 2016, Tomsk, Russia |f National Research Tomsk Polytechnic University (TPU) ; eds. E. Y. Gutmanas ; O. B. Naimark ; Yu. P. Sharkeev |v [020072, 4 p.] |d 2016 | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a радиофармпрепараты | |
| 610 | 1 | |a технеций-99м | |
| 610 | 1 | |a глюкоза | |
| 610 | 1 | |a визуализация | |
| 610 | 1 | |a рак | |
| 610 | 1 | |a опухолевые клетки | |
| 610 | 1 | |a радиоактивность | |
| 701 | 1 | |a Zelchan |b R. V. |c specialist in the field of medical technology |c laboratory Tomsk Polytechnic University |f 1984- |g Roman Vladimirovich |3 (RuTPU)RU\TPU\pers\34194 | |
| 701 | 1 | |a Medvedeva |b А. А. |c specialist in the field of medical technology |c laboratory assistant of Tomsk Polytechnic University, candidate of medical science |f 1975- |g Anna Aleksndrovna |3 (RuTPU)RU\TPU\pers\37376 | |
| 701 | 1 | |a Sinilkin |b I. G. |c specialist in the field of medical technology |c laboratory, Tomsk Polytechnic University, candidate of medical science |f 1972- |g Ivan Gennadjevich |3 (RuTPU)RU\TPU\pers\34189 | |
| 701 | 1 | |a Chernov |b V. I. |c specialist in the field of medical technology |c lead engineer of Tomsk Polytechnic University, doctor of medical sciences |f 1962- |g Vladimir Ivanovich |3 (RuTPU)RU\TPU\pers\34191 | |
| 701 | 1 | |a Stasyuk (Stasiuk) |b E. S. |c Specialist in the field of nuclear power engineering |c Researcher of Tomsk Polytechnic University, Candidate of technical sciences |f 1978- |g Elena Sergeyevna |3 (RuTPU)RU\TPU\pers\32656 |9 16555 | |
| 701 | 1 | |a Rogov |b A. S. |c Radiochemist |c Engineer of Tomsk Polytechnic University |f 1986- |g Alexander Sergeyevich |3 (RuTPU)RU\TPU\pers\32658 | |
| 701 | 1 | |a Ilyina |b E. A. |c physicist, specialist in the field of nuclear physics |c engineer of Tomsk Polytechnic University |f 1990- |g Ekaterina Alekseevna |3 (RuTPU)RU\TPU\pers\34266 | |
| 701 | 1 | |a Larionova |b L. A. |c specialist in the field of radiochemistry |c Senior researcher of Tomsk Polytechnic University |f 1946- |g Lyudmila Aleksandrovna |3 (RuTPU)RU\TPU\pers\36172 |9 19269 | |
| 701 | 1 | |a Skuridin |b V. S. |c Physicist, Specialist in the field of nuclear power engineering |c Professor of Tomsk Polytechnic University, Doctor of technical sciences |f 1946- |g Viktor Sergeyevich |3 (RuTPU)RU\TPU\pers\32655 |9 16554 | |
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