The use of (99m}Tc-Al[2]O[3] for detection of sentinel lymph nodes in breast cancer; AIP Conference Proceedings; Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016
| Parent link: | AIP Conference Proceedings Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016.— 2016.— [020061, 4 p.] |
|---|---|
| Korporativní autor: | |
| Další autoři: | , , , , , , , |
| Shrnutí: | Title screen Purpose: to study the feasibility of using the new radiopharmaceutical based on the technetium-99m-labeled gamma-alumina for identification of sentinel lymph nodes (SLNs) in breast cancer patients. The study included two groups of breast cancer patients who underwent single photon emission computed tomography (SPECT) and intraoperaive gamma probe identification of sentinel lymph nodes (SLNs). To identify SLNs, the day before surgery Group I patients (n=34) were injected with radioactive {99m}Tc-Al[2]O[3], and Group II patients (n=30) received 99mTc-labeled phytate colloid. A total of 37 SLNs were detected in Group I patients. The number of identified SLNs per patient ranged from 1 to 2 (the average number of identified SLNs was 1.08). Axillary lymph nodes were the most common site of SLN localization. 18 hours after {99m}Tc-Al[2]O[3] injection, the percentage of its accumulation in the SLN was 7-11% (of the counts in the injection site) by SPECT and 17-31% by gamma probe detection. In Group II SLNs were detected in 27 patients. 18 hours after injection of the phytate colloid the percentage of its accumulation in the SLN was 1.5-2% out of the counts in the injection site by SPECT and 4-7% by gamma probe. The new radiopharmaceutical based on the {99m}Tc-Al[2]O[3] demonstrates high accumulation in SLNs without redistribution through the entire lymphatic basin. The sensitivity and specificity of {99m}Tc-Al[2]O[3] were 100% for both SPECT and intraoperative gamma probe identification. Режим доступа: по договору с организацией-держателем ресурса |
| Jazyk: | angličtina |
| Vydáno: |
2016
|
| Témata: | |
| On-line přístup: | http://dx.doi.org/10.1063/1.4960280 http://earchive.tpu.ru/handle/11683/35790 |
| Médium: | Elektronický zdroj Kapitola |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652046 |
MARC
| LEADER | 00000nla2a2200000 4500 | ||
|---|---|---|---|
| 001 | 652046 | ||
| 005 | 20250825113326.0 | ||
| 035 | |a (RuTPU)RU\TPU\network\17309 | ||
| 035 | |a RU\TPU\network\17308 | ||
| 090 | |a 652046 | ||
| 100 | |a 20161130a2016 k y0engy50 ba | ||
| 101 | 0 | |a eng | |
| 105 | |a y z 100zy | ||
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a The use of (99m}Tc-Al[2]O[3] for detection of sentinel lymph nodes in breast cancer |f I. G. Sinilkin [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 12 tit.] | ||
| 330 | |a Purpose: to study the feasibility of using the new radiopharmaceutical based on the technetium-99m-labeled gamma-alumina for identification of sentinel lymph nodes (SLNs) in breast cancer patients. The study included two groups of breast cancer patients who underwent single photon emission computed tomography (SPECT) and intraoperaive gamma probe identification of sentinel lymph nodes (SLNs). To identify SLNs, the day before surgery Group I patients (n=34) were injected with radioactive {99m}Tc-Al[2]O[3], and Group II patients (n=30) received 99mTc-labeled phytate colloid. A total of 37 SLNs were detected in Group I patients. The number of identified SLNs per patient ranged from 1 to 2 (the average number of identified SLNs was 1.08). Axillary lymph nodes were the most common site of SLN localization. 18 hours after {99m}Tc-Al[2]O[3] injection, the percentage of its accumulation in the SLN was 7-11% (of the counts in the injection site) by SPECT and 17-31% by gamma probe detection. In Group II SLNs were detected in 27 patients. 18 hours after injection of the phytate colloid the percentage of its accumulation in the SLN was 1.5-2% out of the counts in the injection site by SPECT and 4-7% by gamma probe. The new radiopharmaceutical based on the {99m}Tc-Al[2]O[3] demonstrates high accumulation in SLNs without redistribution through the entire lymphatic basin. The sensitivity and specificity of {99m}Tc-Al[2]O[3] were 100% for both SPECT and intraoperative gamma probe identification. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | 0 | |0 (RuTPU)RU\TPU\network\4816 |t AIP Conference Proceedings | |
| 463 | 0 | |0 (RuTPU)RU\TPU\network\17033 |t Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016 |o Proceedings of the International conference, 22-25 March 2016, Tomsk, Russia |f National Research Tomsk Polytechnic University (TPU) ; eds. E. Y. Gutmanas ; O. B. Naimark ; Yu. P. Sharkeev |v [020061, 4 p.] |d 2016 | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a лимфатические узлы | |
| 610 | 1 | |a рак | |
| 610 | 1 | |a радиофармпрепараты | |
| 610 | 1 | |a эмиссионная томография | |
| 610 | 1 | |a компьютерная томография | |
| 610 | 1 | |a технеций-99м | |
| 610 | 1 | |a онкологические заболевания | |
| 701 | 1 | |a Sinilkin |b I. G. |c specialist in the field of medical technology |c laboratory, Tomsk Polytechnic University, candidate of medical science |f 1972- |g Ivan Gennadjevich |3 (RuTPU)RU\TPU\pers\34189 | |
| 701 | 1 | |a Chernov |b V. I. |c specialist in the field of medical technology |c lead engineer of Tomsk Polytechnic University, doctor of medical sciences |f 1962- |g Vladimir Ivanovich |3 (RuTPU)RU\TPU\pers\34191 | |
| 701 | 1 | |a Medvedeva |b А. А. |c specialist in the field of medical technology |c laboratory assistant of Tomsk Polytechnic University, candidate of medical science |f 1975- |g Anna Aleksndrovna |3 (RuTPU)RU\TPU\pers\37376 | |
| 701 | 1 | |a Zelchan |b R. V. |c specialist in the field of medical technology |c laboratory Tomsk Polytechnic University |f 1984- |g Roman Vladimirovich |3 (RuTPU)RU\TPU\pers\34194 | |
| 701 | 1 | |a Slonimskaya |b E. | |
| 701 | 1 | |a Doroshenko |b A. | |
| 701 | 1 | |a Varlamova |b N. V. |c biochemist |c Researcher of Tomsk Polytechnic University, Candidate of biological sciences |f 1975- |g Natalya Valeryevna |3 (RuTPU)RU\TPU\pers\32659 | |
| 701 | 1 | |a Skuridin |b V. S. |c Physicist, Specialist in the field of nuclear power engineering |c Professor of Tomsk Polytechnic University, Doctor of technical sciences |f 1946- |g Viktor Sergeyevich |3 (RuTPU)RU\TPU\pers\32655 |9 16554 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет (ТПУ) |b Физико-технический институт (ФТИ) |b Лаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР) |3 (RuTPU)RU\TPU\col\20054 |
| 801 | 2 | |a RU |b 63413507 |c 20170120 |g RCR | |
| 856 | 4 | |u http://dx.doi.org/10.1063/1.4960280 | |
| 856 | 4 | |u http://earchive.tpu.ru/handle/11683/35790 | |
| 942 | |c CF | ||