Concurrent thermochemoradiotherapy for brain high-grade glioma
| Parent link: | AIP Conference Proceedings Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016.— 2016.— [020058, 6 p.] |
|---|---|
| Ente Autore: | |
| Altri autori: | , , , , , , , |
| Riassunto: | Title screen Despite the achievements in the current strategies for treatment, the prognosis in malignant glioma patients remains unsatisfactory. Hyperthermia is currently considered to be the most effective and universal modifier of radiotherapy and chemotherapy. Preliminary treatment outcomes for 28 patients with newly diagnosed (23) and recurrent (5) high-grade gliomas were presented. All the patients received multimodality treatment including surgery, thermoche-moradiotherapy followed by 4 cycles of adjuvant chemotherapy. All the patients endured thermochemoradiotherapy well. A complication, limited skin burn (II stage), was diagnosed in two cases and treated conservatively without treatment interruption. A month after thermochemoradiotherapy the results were as follows: complete regression was achieved in 4 cases, partial regression in 4 cases, stable disease in 14 cases and disease progression in 6 cases (one of them is pseudo-progression). After completing the adjuvant chemotherapy 2 more patients demonstrated complete response and 1 patient had disease progression. Introduction of local hyperthermia in multimodal therapy of malignant glioma does not impair the combined modality treatment tolerability of patients with malignant gliomas. A small number of studied patients and short follow-up time do not allow making reliable conclusions about the impact of local hyperthermia on the treatment outcomes; however, there is a tendency towards the increase in disease-free survival in the patients with newly diagnosed malignant gliomas. Режим доступа: по договору с организацией-держателем ресурса |
| Lingua: | inglese |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | http://dx.doi.org/10.1063/1.4960277 http://earchive.tpu.ru/handle/11683/35788 |
| Natura: | Elettronico Capitolo di libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=652044 |
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| 200 | 1 | |a Concurrent thermochemoradiotherapy for brain high-grade glioma |f A. I. Ryabova [et al.] | |
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| 300 | |a Title screen | ||
| 320 | |a [References: 7 tit.] | ||
| 330 | |a Despite the achievements in the current strategies for treatment, the prognosis in malignant glioma patients remains unsatisfactory. Hyperthermia is currently considered to be the most effective and universal modifier of radiotherapy and chemotherapy. Preliminary treatment outcomes for 28 patients with newly diagnosed (23) and recurrent (5) high-grade gliomas were presented. All the patients received multimodality treatment including surgery, thermoche-moradiotherapy followed by 4 cycles of adjuvant chemotherapy. All the patients endured thermochemoradiotherapy well. A complication, limited skin burn (II stage), was diagnosed in two cases and treated conservatively without treatment interruption. A month after thermochemoradiotherapy the results were as follows: complete regression was achieved in 4 cases, partial regression in 4 cases, stable disease in 14 cases and disease progression in 6 cases (one of them is pseudo-progression). After completing the adjuvant chemotherapy 2 more patients demonstrated complete response and 1 patient had disease progression. Introduction of local hyperthermia in multimodal therapy of malignant glioma does not impair the combined modality treatment tolerability of patients with malignant gliomas. A small number of studied patients and short follow-up time do not allow making reliable conclusions about the impact of local hyperthermia on the treatment outcomes; however, there is a tendency towards the increase in disease-free survival in the patients with newly diagnosed malignant gliomas. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
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| 463 | 0 | |0 (RuTPU)RU\TPU\network\17033 |t Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016 |o Proceedings of the International conference, 22-25 March 2016, Tomsk, Russia |f National Research Tomsk Polytechnic University (TPU) ; eds. E. Y. Gutmanas ; O. B. Naimark ; Yu. P. Sharkeev |v [020058, 6 p.] |d 2016 | |
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