The molecular aspects of personalized anticancer treatment
| Parent link: | AIP Conference Proceedings Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016.— 2016.— [020010, 5 p.] |
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| Corporate Author: | |
| Other Authors: | , , , , , |
| Summary: | Title screen Only 25% of cancer patients, on average, benefit from therapy. Even in the cases of complete clinical response the tumor progression is an event of high level expectation. The main reasons for tumor progression are: intratumor heterogeneity resulted from clonal evolution, drug resistance, and tumor-promoting microenvironment. The reprogramming of microenvironmental stromal-inflammatory components is expected to allow tumor phenotype reversion. So, to find the new effective markers of tumor progression, drug response and targets for therapy, it could be promising to take into account the tumor-microenvironment heterogeneity and tumor clonal evolution. Режим доступа: по договору с организацией-держателем ресурса |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1063/1.4960229 http://earchive.tpu.ru/handle/11683/35803 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=651979 |
| Summary: | Title screen Only 25% of cancer patients, on average, benefit from therapy. Even in the cases of complete clinical response the tumor progression is an event of high level expectation. The main reasons for tumor progression are: intratumor heterogeneity resulted from clonal evolution, drug resistance, and tumor-promoting microenvironment. The reprogramming of microenvironmental stromal-inflammatory components is expected to allow tumor phenotype reversion. So, to find the new effective markers of tumor progression, drug response and targets for therapy, it could be promising to take into account the tumor-microenvironment heterogeneity and tumor clonal evolution. Режим доступа: по договору с организацией-держателем ресурса |
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| DOI: | 10.1063/1.4960229 |