Radiopharmaceutical Drug based on Aluminum Oxide; Indian Journal of Science and Technology; Vol. 8, iss. 36
| Parent link: | Indian Journal of Science and Technology.— , 2007- Vol. 8, iss. 36.— 2015.— [90580, 6 p.] |
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| Autor corporatiu: | |
| Altres autors: | , , , , , , , |
| Sumari: | Title screen The regularities of adsorption 99mТс on activated nanoscale powder gamma-oxide Al2O3 were investigated. Methods/Statistical Analysis: As object of examination nanopowder low-temperature (cubic) modification of gamma-oxide Al2O3 is used. The area of specific surface of aluminum oxide was 320 m2/g. According to submicroscopy, the particles had the improper shape and a rough surface. For obtaining of an initial drug 99mTc (eluate) in the form of a sodium pertechnetate solution, 99mTc was produced with the chromatographic generator of “99mTc-GT-TOM” productions of PTI TPU. The stability of the complex was determined by measuring the RCP at room temperature (24°C) at different time points (0, 1, 2, 4 h) after preparation. Findings: It is shown that sorption capacity of aluminum oxide essentially depends on its acid treatment. Experimental research of process of adsorption 99mTc in the presence of reducing agent of tin (II) is made. It’s necessary and sufficient amount providing full “reducibleness” 99mТс in a reaction mixture is spotted. For yield rising nanocolloids with particle size less than 100 nanometers and risings of radiochemical purity of drugs additives of sodium pyrophosphate, ascorbic acid and gelatine were used. Pre-award medicobiological tests of nanocolloids preparate 99mTs-Al2O3 on the observational animals to define the functional operability for scintigraphic visualisation of lymph nodes are conducted. Applications/Improvements: Is of practical importance for carrying out of diagnostic researches in cardiology, oncology and other fields of medicine. |
| Idioma: | anglès |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | http://dx.doi.org/10.17485/ijst/2015/v8i36/90580 |
| Format: | MixedMaterials Electrònic Capítol de llibre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=651718 |
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| 200 | 1 | |a Radiopharmaceutical Drug based on Aluminum Oxide |f V. S. Skuridin [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 12 tit.] | ||
| 330 | |a The regularities of adsorption 99mТс on activated nanoscale powder gamma-oxide Al2O3 were investigated. Methods/Statistical Analysis: As object of examination nanopowder low-temperature (cubic) modification of gamma-oxide Al2O3 is used. The area of specific surface of aluminum oxide was 320 m2/g. According to submicroscopy, the particles had the improper shape and a rough surface. For obtaining of an initial drug 99mTc (eluate) in the form of a sodium pertechnetate solution, 99mTc was produced with the chromatographic generator of “99mTc-GT-TOM” productions of PTI TPU. The stability of the complex was determined by measuring the RCP at room temperature (24°C) at different time points (0, 1, 2, 4 h) after preparation. Findings: It is shown that sorption capacity of aluminum oxide essentially depends on its acid treatment. Experimental research of process of adsorption 99mTc in the presence of reducing agent of tin (II) is made. It’s necessary and sufficient amount providing full “reducibleness” 99mТс in a reaction mixture is spotted. For yield rising nanocolloids with particle size less than 100 nanometers and risings of radiochemical purity of drugs additives of sodium pyrophosphate, ascorbic acid and gelatine were used. Pre-award medicobiological tests of nanocolloids preparate 99mTs-Al2O3 on the observational animals to define the functional operability for scintigraphic visualisation of lymph nodes are conducted. Applications/Improvements: Is of practical importance for carrying out of diagnostic researches in cardiology, oncology and other fields of medicine. | ||
| 461 | |t Indian Journal of Science and Technology |d 2007- | ||
| 463 | |t Vol. 8, iss. 36 |v [90580, 6 p.] |d 2015 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a оксид алюминия | |
| 610 | 1 | |a лекарственные средства | |
| 610 | 1 | |a радиофармацевтические препараты | |
| 610 | 1 | |a реакционные смеси | |
| 701 | 1 | |a Skuridin |b V. S. |c Physicist, Specialist in the field of nuclear power engineering |c Professor of Tomsk Polytechnic University, Doctor of technical sciences |f 1946- |g Viktor Sergeyevich |3 (RuTPU)RU\TPU\pers\32655 |9 16554 | |
| 701 | 1 | |a Sadkin |b V. L. |c Physicist |c Associate Scientist of Tomsk Polytechnic University, candidate of technical Sciences |f 1986- |g Vladimir Leonidovich |3 (RuTPU)RU\TPU\pers\32654 |9 16553 | |
| 701 | 1 | |a Stasyuk (Stasiuk) |b E. S. |c Specialist in the field of nuclear power engineering |c Researcher of Tomsk Polytechnic University, Candidate of technical sciences |f 1978- |g Elena Sergeyevna |3 (RuTPU)RU\TPU\pers\32656 |9 16555 | |
| 701 | 1 | |a Varlamova |b N. V. |c biochemist |c Researcher of Tomsk Polytechnic University, Candidate of biological sciences |f 1975- |g Natalya Valeryevna |3 (RuTPU)RU\TPU\pers\32659 |9 16558 | |
| 701 | 1 | |a Rogov |b A. S. |c Radiochemist |c Engineer of Tomsk Polytechnic University |f 1986- |g Alexander Sergeyevich |3 (RuTPU)RU\TPU\pers\32658 |9 16557 | |
| 701 | 1 | |a Nesterov |b E. A. |c Physicist, Specialist in the field of nuclear power engineering |c Researcher of Tomsk Polytechnic University |f 1976- |g Evgeny Alexandrovich |3 (RuTPU)RU\TPU\pers\32657 |9 16556 | |
| 701 | 1 | |a Ilyina |b E. A. |c physicist, specialist in the field of nuclear physics |c engineer of Tomsk Polytechnic University |f 1990- |g Ekaterina Alekseevna |3 (RuTPU)RU\TPU\pers\34266 |9 17797 | |
| 701 | 1 | |a Larionova |b L. A. |c specialist in the field of radiochemistry |c Senior researcher of Tomsk Polytechnic University |f 1946- |g Lyudmila Aleksandrovna |3 (RuTPU)RU\TPU\pers\36172 |9 19269 | |
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