Neuroprotective effects of p-tyrosol after the global cerebral ischemia in rats

Neuroprotective effects of p-tyrosol after the global cerebral ischemia in rats

Bibliographic Details
Parent link:Phytomedicine
Vol. 23, iss. 7.— 2016.— [P. 784–792]
Corporate Author: Национальный исследовательский Томский политехнический университет Управление проректора по научной работе и инновациям Центр RASA в Томске Лаборатория изучения механизмов нейропротекции
Other Authors: Atochin D. N. Dmitry Nikolaevich, Chernysheva G. A., Smolyakova V. I., Osipenko A. N., Logvinov S. V. S. V., Zhdankina A. A., Sysolyatin S. V., Kryukov Yu. A., Anfinogenova Ya. J. Yana Jonovna, Plotnikova T. M., Plotnikov M. B.
Summary:Title screen
Background. Salidroside is a biologically active compound derived from Rhodiola rosea L. Studies showed that salidroside after i.v. injection is extensively metabolized to p-tyrosol and only trace amounts of salidroside are found in the brain tissue.Objective. The aim of the study was to investigate the neuroprotective effects of p-tyrosol in the global cerebral ischemia-reperfusion (GCI) model.Study design. A total of 103 Wistar rats were assigned to groups of sham-operated (n = 10), control (n = 42), p-tyrosol-treated (n = 36), and pentoxifylline-treated (n = 15) animals. The rats of control, p-tyrosol-treated, and pentoxifylline-treated groups received intravenously 0.9% NaCl solution, 2% solution of p-tyrosol in doses of 5 mg/kg, 10 mg/kg, and 20 mg/kg, and pentoxifylline in a dose of 100 mg/kg, respectively, daily for 5 days. Rats were examined at days 1, 3, and 5 after GCI. After evaluation of neurological deficit, animals were euthanized for morphological and biochemical characterization.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2016
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:http://dx.doi.org/10.1016/j.phymed.2016.03.015
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=651337

Similar Items

Similar Items