Neuroprotective effects of p-tyrosol after the global cerebral ischemia in rats; Phytomedicine; Vol. 23, iss. 7
| Parent link: | Phytomedicine Vol. 23, iss. 7.— 2016.— [P. 784–792] |
|---|---|
| Institution som forfatter: | |
| Andre forfattere: | , , , , , , , , , , |
| Summary: | Title screen Background. Salidroside is a biologically active compound derived from Rhodiola rosea L. Studies showed that salidroside after i.v. injection is extensively metabolized to p-tyrosol and only trace amounts of salidroside are found in the brain tissue.Objective. The aim of the study was to investigate the neuroprotective effects of p-tyrosol in the global cerebral ischemia-reperfusion (GCI) model.Study design. A total of 103 Wistar rats were assigned to groups of sham-operated (n = 10), control (n = 42), p-tyrosol-treated (n = 36), and pentoxifylline-treated (n = 15) animals. The rats of control, p-tyrosol-treated, and pentoxifylline-treated groups received intravenously 0.9% NaCl solution, 2% solution of p-tyrosol in doses of 5 mg/kg, 10 mg/kg, and 20 mg/kg, and pentoxifylline in a dose of 100 mg/kg, respectively, daily for 5 days. Rats were examined at days 1, 3, and 5 after GCI. After evaluation of neurological deficit, animals were euthanized for morphological and biochemical characterization. Режим доступа: по договору с организацией-держателем ресурса |
| Sprog: | engelsk |
| Udgivet: |
2016
|
| Fag: | |
| Online adgang: | http://dx.doi.org/10.1016/j.phymed.2016.03.015 |
| Format: | MixedMaterials Electronisk Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=651337 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 651337 | ||
| 005 | 20250320092741.0 | ||
| 035 | |a (RuTPU)RU\TPU\network\16586 | ||
| 035 | |a RU\TPU\network\16462 | ||
| 090 | |a 651337 | ||
| 100 | |a 20161109d2016 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a Neuroprotective effects of p-tyrosol after the global cerebral ischemia in rats |f D. N. Atochin [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: p. 791-792 (36 tit.)] | ||
| 330 | |a Background. Salidroside is a biologically active compound derived from Rhodiola rosea L. Studies showed that salidroside after i.v. injection is extensively metabolized to p-tyrosol and only trace amounts of salidroside are found in the brain tissue.Objective. The aim of the study was to investigate the neuroprotective effects of p-tyrosol in the global cerebral ischemia-reperfusion (GCI) model.Study design. A total of 103 Wistar rats were assigned to groups of sham-operated (n = 10), control (n = 42), p-tyrosol-treated (n = 36), and pentoxifylline-treated (n = 15) animals. The rats of control, p-tyrosol-treated, and pentoxifylline-treated groups received intravenously 0.9% NaCl solution, 2% solution of p-tyrosol in doses of 5 mg/kg, 10 mg/kg, and 20 mg/kg, and pentoxifylline in a dose of 100 mg/kg, respectively, daily for 5 days. Rats were examined at days 1, 3, and 5 after GCI. After evaluation of neurological deficit, animals were euthanized for morphological and biochemical characterization. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Phytomedicine | ||
| 463 | |t Vol. 23, iss. 7 |v [P. 784–792] |d 2016 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Atochin |b D. N. |c neuroscientist |c The Head of the Laboratory of Tomsk Polytechnic University |f 1960- |g Dmitry Nikolaevich |3 (RuTPU)RU\TPU\pers\37514 |9 20383 | |
| 701 | 1 | |a Chernysheva |b G. A. | |
| 701 | 1 | |a Smolyakova |b V. I. | |
| 701 | 1 | |a Osipenko |b A. N. | |
| 701 | 1 | |a Logvinov S. V. |b S. V. | |
| 701 | 1 | |a Zhdankina |b A. A. | |
| 701 | 1 | |a Sysolyatin |b S. V. | |
| 701 | 1 | |a Kryukov |b Yu. A. | |
| 701 | 1 | |a Anfinogenova |b Ya. J. |c Linguist |c Lecturer of Tomsk Polytechnic University, Doctor of medical sciences |f 1970- |g Yana Jonovna |3 (RuTPU)RU\TPU\pers\33592 |9 17250 | |
| 701 | 1 | |a Plotnikova |b T. M. | |
| 701 | 1 | |a Plotnikov |b M. B. | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Управление проректора по научной работе и инновациям |b Центр RASA в Томске |b Лаборатория изучения механизмов нейропротекции |3 (RuTPU)RU\TPU\col\21815 |9 28136 |
| 801 | 2 | |a RU |b 63413507 |c 20161109 |g RCR | |
| 856 | 4 | |u http://dx.doi.org/10.1016/j.phymed.2016.03.015 | |
| 942 | |c CF | ||