New antirheumatic substance based on phenolic glycoside structure methyl (4-О-Β-glucopyranosyloxy)-benzoic acid; Jurnal Teknologi; Vol. 78, iss. 6-8

Bibliografische gegevens
Parent link:Jurnal Teknologi.— , 1977-
Vol. 78, iss. 6-8.— 2016.— [P. 79-82]
Coauteur: Национальный исследовательский Томский политехнический университет Институт физики высоких технологий Лаборатория № 1
Andere auteurs: Nemtsev A. O. Aleksey Olegovich, Smirnov I. V. Ivan Vladimirovich, Murashko T. O. Tatjyana Olegovna, Ivanov A. A. Aleksey Alekseevich, Bondarev A. A. Aleksandr Aleksandrovich, Udut V. V. Vladimir Vasiljevich
Samenvatting:Title screen
Rheumatoid arthritis (RA) is a chronic inflammatory multifactorial disorder affecting approximately 1% of population, with over 3000000 new cases annually. The principal pharmacological agents are nonsteroidal anti-inflammatory drugs (NSAID). Patients with rheumatoid arthritis are vulnerable to NSAID-associated gastrointestinal complications. Based on these findings we developed a new NSAID agent based on phenolic glycoside structure methyl (4-О-B-glucopyranosyloxy)-benzoic acid. In this study we evaluated the methyl (4-О-B-glucopyranosyloxy)-benzoic acid therapeutic effect in adjuvant-induced rat arthritis compared to etoricoxib effect. According to the results, methyl (4-О-B-glucopyranosyloxy)-benzoic acid activity was superior to etoricoxib, paw volume returned to the initial value 2 days early, than it did in etoricoxib group. Therefore, methyl (4-О-B-glucopyranosyloxy)-benzoic acid might contest to the modern antirheumatic drug etoricoxib.
Режим доступа: по договору с организацией-держателем ресурса
Taal:Engels
Gepubliceerd in: 2016
Onderwerpen:
Online toegang:http://dx.doi.org/10.11113/jt.v78.9058
Formaat: Elektronisch Hoofdstuk
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=651048

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