New antirheumatic substance based on phenolic glycoside structure methyl (4-О-Β-glucopyranosyloxy)-benzoic acid; Jurnal Teknologi; Vol. 78, iss. 6-8
| Parent link: | Jurnal Teknologi.— , 1977- Vol. 78, iss. 6-8.— 2016.— [P. 79-82] |
|---|---|
| Ente Autore: | |
| Altri autori: | , , , , , |
| Riassunto: | Title screen Rheumatoid arthritis (RA) is a chronic inflammatory multifactorial disorder affecting approximately 1% of population, with over 3000000 new cases annually. The principal pharmacological agents are nonsteroidal anti-inflammatory drugs (NSAID). Patients with rheumatoid arthritis are vulnerable to NSAID-associated gastrointestinal complications. Based on these findings we developed a new NSAID agent based on phenolic glycoside structure methyl (4-О-B-glucopyranosyloxy)-benzoic acid. In this study we evaluated the methyl (4-О-B-glucopyranosyloxy)-benzoic acid therapeutic effect in adjuvant-induced rat arthritis compared to etoricoxib effect. According to the results, methyl (4-О-B-glucopyranosyloxy)-benzoic acid activity was superior to etoricoxib, paw volume returned to the initial value 2 days early, than it did in etoricoxib group. Therefore, methyl (4-О-B-glucopyranosyloxy)-benzoic acid might contest to the modern antirheumatic drug etoricoxib. Режим доступа: по договору с организацией-держателем ресурса |
| Lingua: | inglese |
| Pubblicazione: |
2016
|
| Soggetti: | |
| Accesso online: | http://dx.doi.org/10.11113/jt.v78.9058 |
| Natura: | MixedMaterials Elettronico Capitolo di libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=651048 |