New antirheumatic substance based on phenolic glycoside structure methyl (4-О-Β-glucopyranosyloxy)-benzoic acid; Jurnal Teknologi; Vol. 78, iss. 6-8
| Parent link: | Jurnal Teknologi.— , 1977- Vol. 78, iss. 6-8.— 2016.— [P. 79-82] |
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| Autor corporatiu: | |
| Altres autors: | , , , , , |
| Sumari: | Title screen Rheumatoid arthritis (RA) is a chronic inflammatory multifactorial disorder affecting approximately 1% of population, with over 3000000 new cases annually. The principal pharmacological agents are nonsteroidal anti-inflammatory drugs (NSAID). Patients with rheumatoid arthritis are vulnerable to NSAID-associated gastrointestinal complications. Based on these findings we developed a new NSAID agent based on phenolic glycoside structure methyl (4-О-B-glucopyranosyloxy)-benzoic acid. In this study we evaluated the methyl (4-О-B-glucopyranosyloxy)-benzoic acid therapeutic effect in adjuvant-induced rat arthritis compared to etoricoxib effect. According to the results, methyl (4-О-B-glucopyranosyloxy)-benzoic acid activity was superior to etoricoxib, paw volume returned to the initial value 2 days early, than it did in etoricoxib group. Therefore, methyl (4-О-B-glucopyranosyloxy)-benzoic acid might contest to the modern antirheumatic drug etoricoxib. Режим доступа: по договору с организацией-держателем ресурса |
| Idioma: | anglès |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | http://dx.doi.org/10.11113/jt.v78.9058 |
| Format: | MixedMaterials Electrònic Capítol de llibre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=651048 |
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| 200 | 1 | |a New antirheumatic substance based on phenolic glycoside structure methyl (4-О-Β-glucopyranosyloxy)-benzoic acid |f A. O. Nemtsev [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: p. 81-82 (25 tit.)] | ||
| 330 | |a Rheumatoid arthritis (RA) is a chronic inflammatory multifactorial disorder affecting approximately 1% of population, with over 3000000 new cases annually. The principal pharmacological agents are nonsteroidal anti-inflammatory drugs (NSAID). Patients with rheumatoid arthritis are vulnerable to NSAID-associated gastrointestinal complications. Based on these findings we developed a new NSAID agent based on phenolic glycoside structure methyl (4-О-B-glucopyranosyloxy)-benzoic acid. In this study we evaluated the methyl (4-О-B-glucopyranosyloxy)-benzoic acid therapeutic effect in adjuvant-induced rat arthritis compared to etoricoxib effect. According to the results, methyl (4-О-B-glucopyranosyloxy)-benzoic acid activity was superior to etoricoxib, paw volume returned to the initial value 2 days early, than it did in etoricoxib group. Therefore, methyl (4-О-B-glucopyranosyloxy)-benzoic acid might contest to the modern antirheumatic drug etoricoxib. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Jurnal Teknologi |d 1977- | ||
| 463 | |t Vol. 78, iss. 6-8 |v [P. 79-82] |d 2016 | ||
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| 610 | 1 | |a нестероидные противовоспалительные препараты | |
| 610 | 1 | |a фенольные гликозиды | |
| 610 | 1 | |a адъюванты | |
| 701 | 1 | |a Nemtsev |b A. O. |g Aleksey Olegovich | |
| 701 | 1 | |a Smirnov |b I. V. |g Ivan Vladimirovich | |
| 701 | 1 | |a Murashko |b T. O. |g Tatjyana Olegovna | |
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| 701 | 1 | |a Bondarev |b A. A. |g Aleksandr Aleksandrovich | |
| 701 | 1 | |a Udut |b V. V. |g Vladimir Vasiljevich | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Институт физики высоких технологий |b Лаборатория № 1 |3 (RuTPU)RU\TPU\col\19035 |9 27311 |
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