Multifunctional polyelectrolyte microcapsules as a contrast agent for photoacoustic imaging in blood

Multifunctional polyelectrolyte microcapsules as a contrast agent for photoacoustic imaging in blood

Bibliographic Details
Parent link:Journal of Biophotonics.— , [s. a.]
Vol. 9, iss. 8.— 2016.— [P. 792-799]
Corporate Author: Национальный исследовательский Томский политехнический университет Управление проректора по научной работе и инновациям Центр RASA в Томске Лаборатория новых лекарственных форм
Other Authors: Yashchenok A. M. Alexey M., Jithin J. Jose, Trochet Ph. Philippe, Sukhorukov G. B. Gleb Borisovich, Gorin D. A. Dmitry Aleksandrovich
Summary:Title screen
The polyelectrolyte microcapsules that can be accurate either visualized in biological media or in tissue would enhance their further in vivo application both as a carrier of active payloads and as a specific sensor. The immobilization of active species, for instance fluorescent dyes, quantum dots, metal nanoparticles, in polymeric shell enables visualization of capsules by optical imaging techniques in aqueous solution. However, for visualization of capsules in complex media an instrument with high contrast modality requires. Herein, we show for the first time photoacoustic imaging (PAI) of multifunctional microcapsules in water and in blood. The microcapsules exhibit greater photoacoustic intensity compare to microparticles with the same composition of polymeric shell presumably their higher thermal expansion. Photoacoustic intensity form microcapsules dispersed in blood displays an enhancement (2-fold) of signal compare to blood. Photoacoustic imaging of microcapsules might contribute to non-invasive carrier visualization and further their in vivo distribution.
Режим доступа: по договору с организацией-держателем ресурса
Published: 2016
Subjects:
электронный ресурс
труды учёных ТПУ
микрокапсулы
томография
Online Access:http://dx.doi.org/10.1002/jbio.201500293
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=650982

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